JAM-A / Junctional Adhesion Molecule A Protein, Mouse, Recombinant (Fc Tag)

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JAM-A / Junctional Adhesion Molecule A Protein, Mouse, Recombinant (Fc Tag): Product Information

Purity
> 94 % as determined by SDS-PAGE
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method
Activity
Testing in progress
Protein Construction
A DNA sequence encoding the mouse F11R (NP_766235.1) extracellular domain (Met 1-Ala 242) was fused with the Fc region of human IgG1 at the C-terminus.
Accession#
Expressed Host
HEK293 Cells
Species
Mouse
Predicted N Terminal
Lys 27
Molecule Mass
The secreted recombinant mouse F11R/Fc is a disulfide-linked homodimeric protein. The reduced monomer comprises 457 amino acids and has a predicted molecular mass of 50.2 kDa. rmF11R/Fc monomer migrates as an is approximately 57 kDa band in SDS-PAGE under reducing conditions, with ~10% free Fc fragment.
Formulation
Lyophilized from sterile PBS, pH 7.4
1. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
2. Please contact us for any concerns or special requirements.
Please refer to the specific buffer information in the hard copy of CoA.
Shipping
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Stability & Storage
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃
Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

JAM-A / Junctional Adhesion Molecule A Protein, Mouse, Recombinant (Fc Tag): Images

JAM-A / Junctional Adhesion Molecule A Protein, Mouse, Recombinant (Fc Tag): Alternative Names

9130004G24 Protein, Mouse; AA638916 Protein, Mouse; ESTM33 Protein, Mouse; JAM Protein, Mouse; JAM-1 Protein, Mouse; JAM-A Protein, Mouse; Jcam Protein, Mouse; Jcam1 Protein, Mouse; Ly106 Protein, Mouse

JAM-A / Junctional Adhesion Molecule A Background Information

Junctional adhesion molecule-A (JAM-A), also known as F11 receptor (F11R) or Cluster of Differentiation 321 (CD321), is a transmembrane protein expressed at tight junctions of epithelial and endothelial cells, as well as on circulating leukocytes. JAM-A protein serves as a serotype-independent receptor for mammalian orthoreoviruses (reoviruses). It is also a ligand for the integrin LFA1, involves in leukocyte transmigration. As a cell adhesion molecule of the immunoglobulin superfamily, JAM-A protein involves in platelet adhesion, secretion and aggregation, and plays a crucial role in inflammatory thrombosis and atherosclerosis. In addition, it may be a potential therapeutic target for breast cancer.
Full Name
F11 receptor
References
  • Guglielmi KM, et al. (2007) Reovirus binding determinants in junctional adhesion molecule-A. J Biol Chem. 282(24): 17930-40.
  • Yeung D, et al. (2008) Decreased junctional adhesion molecule-A expression during blood-brain barrier breakdown. Acta Neuropathol. 115(6): 635-42.
  • Ong KL, et al. (2009) Elevated plasma level of soluble F11 receptor/junctional adhesion molecule-A (F11R/JAM-A) in hypertension. Am J Hypertens. 22(5): 500-5.
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