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IL-6家族及其受體

IL-6 Family & Receptor

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    IL-6家族及其受體 Background

    Interleukin-6 (IL-6) family of cytokines includes IL-6, IL-11, leukemia inhibitory factor (LIF), oncostatin M (OSM), ciliary neurotrophic factor (CNTF), cardiotrophin-like cytokine (CLC) and cardiotrophin-1 (CT-1). The IL-6 family cytokines exhibit a four-helix bundle structure. In addition, the receptors of the IL-6 family cytokines share a receptor subunit, which explains one of the mechanisms of functional redundancy. Members of the IL-6 family cytokines utilize one or both of the shared receptor signal transducing subunits, gp130 and LIF receptor (LIFR). IL-31 has also been placed in IL-6 family due to its four-helix bundle structure. IL-6 family binding of gp130 activates the JAK/STAT signaling pathway. Cytokines belonging to the IL-6 family function in many biological processes. IL-6 and IL-16 receptor have been implicated in prostate cancer progression.

    Leptin, the ob (obese) gene product, has a structure similar to that of the IL-6 family of cytokines. Furthermore, its receptor (Ob-R) is homologous to gp130. Both Janus kinases and signal transducers and activators of transcription are involved as downstream components of leptin and IL-6 signaling, which demonstrates several similarities between leptin and the IL-6 family.

    IL-6家族及其受體 References

      1. Gyotoku E, et al. (2001) The IL-6 family cytokines, interleukin-6, interleukin-11, oncostatin M, and leukemia inhibitory factor, enhance mast cell growth through fibroblast-dependent pathway in mice. Arch Dermatol Res. 293(10):508-14.
      2. Derouet D, et al. (2004) Neuropoietin, a new IL-6-related cytokine signaling through the ciliary neurotrophic factor receptor. Proc Natl Acad Sci. 101(14): 4827-32.
      3. Hibi M, et al. (1996) IL-6 cytokine family and signal transduction: a model of the cytokine system. J Mol Med. 74(1):1-12.
      4. Quinton LJ, et al. (2008) Alveolar epithelial STAT3, IL-6 family cytokines, and host defense during Escherichia coli pneumonia. Am J Respir Cell Mol Biol. 38(6):699-706.