Influenza Hemagglutinin (HA) Protein Structure

Q1: Structure of Influenza

Influenza Viruses is a viral infection of the respiratory and pulmonary system generally accompanied by fever. It is hard to prevent influenza because it is contracted simply by the act of breathing. There are necleopretein, P protein and RNA in the center of a influenza virus and the center domain is surrounded by capsid and lipid envelope from inside to outside. On the surface of influenza, there are Hemagglutinin (HA) and Neuraminidase (NA), both of which serve as antigenic proteins. In a word, the influenza virus is composed of a lipid bilayer with hemagglutinin and neuraminidase attached to it.

influenza virus

Q2: Structure of Hemagglutinin (HA)

Hemagglutinin (HA) is a glycoprotein that binds the virus to the cell being infected. The hemagglutinin molecule is actually a combination of three identical proteins (shown here as gray, green, and purple) that are bound together to form an elongated cylindrical shape. Hemagglutinin consists of a globular head and a stem. The globular head consists of three chains, Chains A, C, and E. The stem of the protein consists of three chains as well, Chains B, D, and F. The head of the protein has been noted to vary in structure and function where the stem, or glycan, has been noted to be more conserved in structure and function. The function of chains A, C, and E is the binding of influenza to pulmonary cells and the start of endocytosis.

hemagglutinin

Q3: Structure of Neuraminidase (NA)

Neuraminidase (NA)is an enzyme that helps the virus to breach cell walls. Neuraminidase is also known as sialidase because it breaks the linkages between sialic acid and cellular glycoproteins and glycolipids found in cell walls. Neuraminidase forms mushroom-like projections on the surface of the influenza virus. The top consists of four identical proteins with a roughly spherical shape. The picture below shows how each of these subunits is rotated by 90 degrees relative to the center of the arrangement.

structure of neuraminidase

Influenza Research Reagents (Hot!)

Influenza virus antigen protein

Product Name Cat No.
Influenza H1N1 (A/California/07/2009) Hemagglutinin 11085-V08H
Influenza H1N1 (A/Puerto Rico/8/1934) Hemagglutinin 11684-V08H
Influenza H1N1 (A/California/04/2009) Hemagglutinin 11055-V08H
Influenza H1N1 (A/California/04/2009) Hemagglutinin 11055-V08B
Influenza H3N2 (A/Aichi/2/1968) Hemagglutinin 11707-V08H
Influenza H3N2 (A/Brisbane/10/2007) Hemagglutinin 11056-V08H
Influenza H5N1 (A/Anhui/1/2005) Hemagglutinin 11048-V08H1
Influenza H3N2 Virus Hemagglutinin Protein 40043-V08H
Influenza H7N9 (A/Anhui/1/2013) Hemagglutinin Protein 40103-V08B
Influenza H1N1 (A/Brisbane/59/2007) Hemagglutinin 11052-V08H
Influenza H5N1 (A/VietNeuraminidasem/1194/2004) Hemagglutinin 11062-V08H1
Influenza H7N9 (A/Anhui/1/2013) Hemagglutinin Protein 40103-V08H
Influenza H5N1 (A/Anhui/1/2005) Hemagglutinin 11048-V08H4
Influenza H1N1 (A/California/07/2009) Hemagglutinin Protein 11085-V08B
Influenza H1N1 Nucleoprotein Protein 11675-V08B
Influenza H1N1 (A/California/07/09) Nucleoprotein Protein 40205-V08B
Influenza H1N1 (A/California/04/2009 )Neuraminidase Protein (Active) 11058-V07B
Influenza H5N1 Neuraminidase (Active) 11676-VNAHC
Influenza H5N1 (A/Hubei/2011) Neuraminidase Protein (Active) 40018-V07H
Influenza H1N1 (A/Puerto Rico/8/34/Mount SiNeuraminidasei) Matrix Protein 1 40010-V07E

Influenza virus antigen antibody

Product Name Cat No.
Influenza H1N1 (Swine Flu 2009) Hemagglutinindy Antibo 11055-MM01
Influenza H1N1 (Swine Flu 2009) Hemagglutinin Antibody 11055-RM05
Influenza H7N9 Hemagglutinin Antibody, Rabbit Pab 40103-RP02
Influenza H1N1 (Swine) Hemagglutinin Antibody 11055-MM09
Influenza H1N1 Hemagglutinin Antibody 11684-RP01
Influenza H1N1 (Swine Flu 2009) Hemagglutinin Antibody 11055-RP02
Influenza H5N1 (Avian Flu) Hemagglutinin Antibody 11048-MM01
Influenza Virus Hemagglutinin Antibody, Rabbit MAb 86001-RM01
Influenza H3N2 Hemagglutinin Antibody 11056-MM03
Influenza H1N1 (Swine Flu 2009) Neuraminidase Antibody 11058-R001
All influenza Reasearch Reagents
Browse by Product Type
influenza Protein
influenza Antibody
influenza ELISA Kit
influenza cDNA Clone
Browse by Target
HA
M1
M2
NA
NP
NS1
NS2
PA
PB1
PB2
Browse by Subtype
H1N1
H1N2
H1N3
H1N8
H1N9
H2N2
H2N3
H2N8
H3N1
H3N2
H3N8
H4N2
H4N4
H4N6
H4N8
H5N1
H5N2
H5N3
H5N6
H5N8
H5N9
H6N1
H6N2
H6N4
H6N5
H6N6
H6N8
H7N1
H7N2
H7N3
H7N7
H7N8
H7N9
H8N4
H9N1
H9N2
H9N5
H9N8
H10N3
H10N4
H10N7
H10N8
H10N9
H11N2
H11N6
H11N9
H12N1
H12N3
H12N5
H13N6
H13N8
H14N5
H15N2
H15N8
H16N3
H17N10
H18N11
Influenza B
Browse by Strains
A/Shanghai/1/2013
A/Anhui/1/2013
A/Hangzhou/1/2013
A/pigeon/Shanghai/S1069/2013
A/California/04/2009
A/California/07/2009
A/Beijing/22808/2009
A/England/195/2009
A/New York/18/2009
A/Ohio/07/2009
A/Texas/05/2009
A/Anhui/1/2005
A/turkey/Turkey/1/2005
A/Indonesia/5/2005
A/Vietnam/1203/2004
A/Vietnam/1194/2004
A/chicken/Netherlands/1/03
A/Hong Kong/1073/99
A/Aichi/2/1968
A/Japan/305/1957
A/Brevig Mission/1/1918
See more Strains
Reagents for pandemic influenza
2013 H7N9
2009 Influenza Pandemic (H1N1 Swine Flu)
1968 Influenza Pandemic (Hong Kong Flu)
1957 Influenza Pandemic (Asian Flu)
1918 influenza pandemic (Spanish Flu)
H5N1 Influenza Pandemic Threat (Avian Flu)
H7N7 Influenza Pandemic Threat
H9N2 Influenza Pandemic Threat
Influenza related information
Influenza Hemagglutinin (HA) Protein General Information
Influenza Hemagglutinin (HA) Protein Structure
Influenza Hemagglutinin (HA) Protein Function
Influenza Hemagglutinin (HA) Subtypes and Flu Virus Strains
Influenza A H3N2 General Information
Influenza A H9N2 General Information