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甲型流感 H5N1 (A/Thailand/1(KAN-1)/2004) 神經氨酸酶 (Neuraminidase / NA) 蛋白 (His 標籤), Biotinylated

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H5N1 NA 蛋白產品資訊
分子別稱:NA
蛋白構建:A DNA sequence encoding the influenza A virus (A/Thailand/1(KAN-1)/2004(H5N1)) neuraminidase (His36-Ile469), termed as NA, was fused with a N-terminal polyhistidine tag. The expressed protein was biotinylated in vitro.
分子種屬:H5N1
表達宿主:Human Cells
#N/A:In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
H5N1 NA 蛋白質控檢測
純度:> 65 % as determined by SDS-PAGE
內毒素:< 1.0 EU per μg protein as determined by the LAL method.
穩定性:Samples are stable for up to twelve months from date of receipt at -70℃
預測N端:His
分子量:The recombinant NA subunit of influenza A H5N1 (A/Thailand/1(KAN-1)/2004(H5N1)) comprises 433 amino acids and has a predicted molecular mass of 47.6 kDa. It migrates as an approximately 55 kDa band in SDS-PAGE under reducing conditions.
緩衝液:Lyophilized from sterile PBS , pH 7.4.
1. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
2. Please contact us for any concerns or special requirements.
H5N1 NA 蛋白使用指導
儲存方法:Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
#N/A:A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
H5N1 NA Protein SDS-PAGE
Influenza A H5N1 (A/Thailand/1(KAN-1)/2004) Neuraminidase / NA Protein (His Tag), Biotinylated

NA 相關信號通路

    Other NA Recombinant Protein Products
    Neuraminidase 研究背景

    Neuraminidases are enzymes that cleave sialic acid groups from glycoproteins. Influenza neuraminidase is a type of neuraminidase found on the surface of influenza viruses that enables the virus to be released from the host cell.

    Influenza neuraminidase is composed of four identical subunits arranged in a square. It is normally attached to the virus surface through a long protein stalk. The active sites are in a deep depression on the upper surface. They bind to polysaccharide chains and clip off the sugars at the end. The surface of neuraminidase is decorated with several polysaccharide chains that are similar to the polysaccharide chains that decorate our own cell surface proteins.

    Neuraminidase (NA) and hemagglutinin (HA) are major membrane glycoproteins found on the surface of influenza virus. Hemagglutinin binds to the sialic acid-containing receptors on the surface of host cells during initial infection and at the end of an infectious cycle. Neuraminidase, on the other hand, cleaves the HA-sialic acid bondage from the newly formed virions and the host cell receptors during budding. Neuraminidase thus is described as a receptor-destroying enzyme which facilitates virus release and efficient spread of the progeny virus from cell to cell.

    Influenza antibody and influenza antibodies are very important research tools for influenza diagnosis, influenza vaccine development, and anti-influenza virus therapy development. Monoclonal or polyclonal antibody can be raised with protein based antigen or peptide based antigen. Antibody raised with protein based antigen could have better specificity and/or binding affinity than antibody raised with peptide based antigen, but cost associated with the recombinant protein antigen is usually higher. Anti influenza virus hemagglutinin (HA) monoclonal antibody or polyclonal antibody can be used for ELISA assay, western blotting detection, Immunohistochemistry (IHC), flow cytometry, neutralization assay, hemagglutinin inhibition assay, and early diagnosis of influenza viral infection.

    Sino Biological has developed state-of-the-art monoclonal antibody development technology platforms: mouse monoclonal antibody and rabbit monoclonal antibody. Our rabbit monoclonal antibody platform is one of a kind and offers some unique advantages over mouse monoclonal antibodies, such as high affinity, low cross-reactivity with rabbit polyclonal antibodies.

    H5N1 Neuraminidase 參考資料
  • Sardet C., et al.,(1989), Molecular cloning, primary structure, and expression of the human growth factor-activatable Na+/H+ antiporter. Cell 56:271-280.
  • Sardet C., et al., (1990), Growth factors induce phosphorylation of the Na+/H+ antiporter, glycoprotein of 110 kD.Science 247:723-726.
  • Tse C.-M., et al.,(1991), Molecular cloning and expression of a cDNA encoding the rabbit ileal villus cell basolateral membrane Na+/H+ exchanger.EMBO J. 10:1957-1967.
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    貨號: 40064-V07H-B-10
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    • Influenza A H5N1 (A/Thailand/1(KAN-1)/2004) Neuraminidase / NA Protein (His Tag), Biotinylated
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