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甲型流感 H10N8 血凝素 (Hemagglutinin / HA) 中和抗體

  • Influenza A H10N8 Hemagglutinin / HA Neutralizing Antibody
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H10N8 HA 抗體產品資訊
免疫原:Recombinant Influenza A H10N8 (A/Jiangxi-Donghu/346/2013) Hemagglutinin / HA protein (Catalog#40359-V08B)
Clone ID:mh001
Ig類型:mouse (varialbe region) / human (kappa / IgG1
濃度:
內毒素:Please contact us for more information.
緩衝液:0.2 μm filtered solution in PBS
抗體製備方法:It is a chimeric monoclonal antibody combining the constant domains of the human IgG1 molecule with mouse variable regions. The variable region was obtained from a mouse immunized with purified, recombinant Influenza A H10N8 (A/Jiangxi-Donghu/346/2013) Hemagglutinin / HA. The antibody was produced using recombinant antibody technology.
H10N8 HA Antibody Neutralization Application Image
Influenza A H10N8 Hemagglutinin / HA Neutralizing Antibody
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Caption:
The neutralization activity of H10N8 HA protein antibody is Measured by Microneutralization test in vitro. The pseudovirus microneutralizaiton (MN) test was performed on 293FT cells infected with H10N8 (A/Jiangxi-Donghu/346/2013) pseudovirus under the treatment of serial dilution of Neutralizing Antibody. The infection with high titer H10N8 pseduotype virus is inhibited completely under 1 µg/mL influenza A H10N8 HA Neutralizing Antibody (Catalog 40359-mh001).
Other HA Antibody Products
Immunochemical staining of human CD40 in human tonsil with rabbit polyclonal antibody (0.5 µg/mL, formalin-fixed paraffin embedded sections).
HA 研究背景

The influenza viral Hemagglutinin (HA) protein is a homo trimer with a receptor binding pocket on the globular head of each monomer.HA has at least 18 different antigens. These subtypes are named H1 through H18.HA has two functions. Firstly, it allows the recognition of target vertebrate cells, accomplished through the binding to these cells' sialic acid-containing receptors. Secondly, once bound it facilitates the entry of the viral genome into the target cells by causing the fusion of host endosomal membrane with the viral membrane.The influenza virus Hemagglutinin (HA) protein is translated in cells as a single protein, HA0, or hemagglutinin precursor protein. For viral activation, hemagglutinin precursor protein (HA0) must be cleaved by a trypsin-like serine endoprotease at a specific site, normally coded for by a single basic amino acid (usually arginine) between the HA1 and HA2 domains of the protein. After cleavage, the two disulfide-bonded protein domains produce the mature form of the protein subunits as a prerequisite for the conformational change necessary for fusion and hence viral infectivity.

H10N8 HA 參考資料
  • White JM, Hoffman LR, Arevalo JH, et al. (1997). "Attachment and entry of influenza virus into host cells. Pivotal roles of hemagglutinin". In Chiu W, Burnett RM, Garcea RL. Structural Biology of Viruses.
  • Suzuki Y (March 2005). "Sialobiology of influenza: molecular mechanism of host range variation of influenza viruses". Biol. Pharm. Bull. 28 (3): 399–408.
  • Senne DA, Panigrahy B, Kawaoka Y, et al. (1996). "Survey of the hemagglutinin (HA) cleavage site sequence of H5 and H7 avian influenza viruses: amino acid sequence at the HA cleavage site as a marker of pathogenicity potential". Avian Dis. 40 (2): 425–37
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    貨號: 40359-mh001-500
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    Datasheet & Documentation

    All information of our products is subject to change without notice. Please refer to COA enclosed in shipped package for the newest information.
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