|Recombinant Influenza A H10N8 (A/Jiangxi-Donghu/346/2013) Hemagglutinin / HA protein (Catalog#40359-V08B)|
|mouse (varialbe region) / human (kappa / IgG1|
|Please contact us for more information.|
|0.2 μm filtered solution in PBS|
|It is a chimeric monoclonal antibody combining the constant domains of the human IgG1 molecule with mouse variable regions. The variable region was obtained from a mouse immunized with purified, recombinant Influenza A H10N8 (A/Jiangxi-Donghu/346/2013) Hemagglutinin / HA. The antibody was produced using recombinant antibody technology.|
Has cross-reactivity with H10N3 (A/duck/Hong Kong/786/1979) Hemagglutinin (Catalog # 11693-V08H) / H10N8 (A/duck/Guangdong/E1/2012) Hemagglutinin (Catalog # 40351-V08H1)
No cross-reactivity with H10N3 (A/mallard/Minnesota/Sg-00194/2007) Hemagglutinin (Catalog # 40184-V08B) in ELISA assay.
This H10N8 HA protein Neutralizing Antibody can block the binding of the recombinant H10N8 HA protein to sialic acid and inhibit the hemagglutinin activity of recombinant H10N8 HA protein. The HI titer is 0.1-0.4 µg/mL When 1 unit of H10N8 HA protein (Catalog # 40359-V08B) added.
This H10N8 HA protein Neutralizing Antibody can block the binding of the recombinant H10N8 HA protein to sialic acid and inhibit the hemagglutinin activity of recombinant H10N8 HA protein. The HI titer is 0.1-0.4 µg/mL When 1 unit of H10N8 HA protein (40359-V08B) added.
The influenza viral Hemagglutinin (HA) protein is a homo trimer with a receptor binding pocket on the globular head of each monomer.HA has at least 18 different antigens. These subtypes are named H1 through H18.HA has two functions. Firstly, it allows the recognition of target vertebrate cells, accomplished through the binding to these cells' sialic acid-containing receptors. Secondly, once bound it facilitates the entry of the viral genome into the target cells by causing the fusion of host endosomal membrane with the viral membrane.The influenza virus Hemagglutinin (HA) protein is translated in cells as a single protein, HA0, or hemagglutinin precursor protein. For viral activation, hemagglutinin precursor protein (HA0) must be cleaved by a trypsin-like serine endoprotease at a specific site, normally coded for by a single basic amino acid (usually arginine) between the HA1 and HA2 domains of the protein. After cleavage, the two disulfide-bonded protein domains produce the mature form of the protein subunits as a prerequisite for the conformational change necessary for fusion and hence viral infectivity.