|Anti-IL-18 Magnetic Beads1,3||2-8℃ for 12 months|
|NP40 Cell Lysis Buffer2||-20℃ for 12 months|
|CD166 Positive Cell Lysate||-20℃ for 12 months|
|Alkaline Elution Buffer||2-8℃ for 12 months|
|Acidity Elution Buffer||2-8℃ for 12 months|
|Neutralization Buffer||2-8℃ for 12 months|
 The IP KIT contains anti-IL-18 magnetic Beads (2 mg/mL) in phosphate buffered saline (PBS, pH 7.4) with sodium azide (0.1%).
 Using NP-40 cell lysate buffer in the kit is required,otherwise,the magnetic beads may be precipitated.
 Shipping: Magnetic Beads kits are shipped at ambient temperature in which magnetic beads are provided in liquid buffer.
Interleukin-18 (IL-18, also known as interferon-gamma inducing factor) is a proinflammatory cytokine that belongs to the IL-1 superfamily and is produced by macrophages and other cells. This cytokine can induce the IFN-gamma production of T cells. The combination of IL-18 and IL12 has been shown to inhibit IL4 dependent IgE and IgG1 production, and enhance IgG2a production of B cells. IL-18 binding protein (IL18BP) can specifically interact with this cytokine, and thus negatively regulate its biological activity. IL-18 is an IL-1−like cytokine that requires cleavage with caspase-1 to become active, was found to increase IgE production in a CD4+ T cells-, IL-4− and STAT6−dependent fashion. IL-18 and T cell receptor−mediated stimulation could induce naïve CD4+ T cells to develop into IL-4−producing cells in vitro. Thus, caspase-1 and IL-18 may be critical in regulation of IgE production in vivo, providing a potential therapeutic target for allergic disorders. IL-18 production in primary synovial cultures and purified synovial fibroblasts was, in turn, upregulated by TNF-α and IL-1β, suggesting that monokine expression can feed back to promote Th1 cell development in synovial membrane. Besides, synergistic combinations of IL-18, IL-12, and IL-15 may be of importance in sustaining both Th1 responses and monokine production in RA.
|Immunoprecipitation Kit -Immunomagnetic Beads Protein A/G||BAG001|
|Immunoprecipitation Kit -DYKDDDDK（Flag®）Tag Immunomagnetic Beads||TB101274|
|MagpoinsTM His-Tag Immunoprecipitation KIT||TBN001|
|Simple Magnetic Separator||MAGS001|
|Immunoprecipitation Kit -HA Tag Immunomagnetic Beads||TB100028|
|Immunoprecipitation Kit -V5 Tag Immunomagnetic Beads||TB100378|
|Immunoprecipitation Kit -Immunomagnetic Beads Protein A||BA10600|
|Immunoprecipitation Kit -Immunomagnetic Beads Protein L||BL11044|
|Immunoprecipitation Kit -GFP Tag Immunomagnetic Beads||TB13105|
|Immunoprecipitation Kit -Immunomagnetic Beads Protein G||BG13103|
|Immunoprecipitation Kit -MYC Tag Immunomagnetic Beads||TB100029|
|Immunoprecipitation Kit -GST Tag Immunomagnetic Beads||TB11213|