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CD61/Integrin beta 3/ITGB3  Protein, Antibody, ELISA Kit, cDNA Clone

CD61/Integrin beta 3/ITGB3 相关研究领域

CD61/Integrin beta 3/ITGB3 相關信號通路

CD61/Integrin beta 3/ITGB3 概述&蛋白信息

CD61/Integrin beta 3/ITGB3 研究背景

亞單位結構: Heterodimer of an alpha and a beta subunit. Beta-3 (ITGB3) associates with either alpha-IIb (ITGA2B) or alpha-V (ITGAV). Isoform Beta-3C interacts with FLNB. Interacts with COMP. Interacts with PDIA6 following platelet stimulation. Interacts with SYK; upon activation by ITGB3 promotes platelet adhesion. Interacts with MYO10. Interacts with DAB2. Interacts with FERMT2. Interacts with EMP2; regulates the levels of the heterodimer ITGA5:ITGB3 integrin expression on the plasma membrane (PubMed:16216233). Integrin ITGAV:ITGB3 interacts with FBLN5 (via N-terminus) (By similarity). Integrin ITGAV:ITGB3 interacts with herpes virus 8/HHV-8 glycoprotein B and acts as a receptor for the virus. Interacts with HIV-1 Tat. {ECO:0000250|UniProtKB:O54890, ECO:0000269|PubMed:10397733, ECO:0000269|PubMed:11807098, ECO:0000269|PubMed:11940607, ECO:0000269|PubMed:15156152, ECO:0000269|PubMed:15466936, ECO:0000269|PubMed:16051604, ECO:0000269|PubMed:16216233, ECO:0000269|PubMed:17583734, ECO:0000269|PubMed:18045938, ECO:0000269|PubMed:20702409}.
亞細胞定位: Cell membrane {ECO:0000269|PubMed:20020534, ECO:0000269|PubMed:20702409, ECO:0000269|PubMed:9195946}; Single-pass type I membrane protein {ECO:0000269|PubMed:20020534, ECO:0000269|PubMed:20702409, ECO:0000269|PubMed:9195946}. Cell projection, lamellipodium membrane {ECO:0000269|PubMed:20702409}. Cell junction, focal adhesion {ECO:0000269|PubMed:20702409}.
組織特異性: Isoform beta-3A and isoform beta-3C are widely expressed. Isoform beta-3A is specifically expressed in osteoblast cells; isoform beta-3C is specifically expressed in prostate and testis.
翻譯後修飾: Phosphorylated on tyrosine residues in response to thrombin-induced platelet aggregation. Probably involved in outside-in signaling. A peptide (AA 740-762) is capable of binding GRB2 only when both Tyr-773 and Tyr-785 are phosphorylated. Phosphorylation of Thr-779 inhibits SHC binding. {ECO:0000269|PubMed:10896934}.
相關疾病 : DISEASE: Glanzmann thrombasthenia (GT) [MIM:273800]: A common inherited disease of platelet aggregation. It is characterized by mucocutaneous bleeding of mild-to-moderate severity. GT has been classified clinically into types I and II. In type I, platelets show absence of the glycoprotein IIb-IIIa complexes at their surface and lack fibrinogen and clot retraction capability. In type II, the platelets express the GPIIb-IIIa complex at reduced levels, have detectable amounts of fibrinogen, and have low or moderate clot retraction capability. {ECO:0000269|PubMed:10233432, ECO:0000269|PubMed:11588040, ECO:0000269|PubMed:11897046, ECO:0000269|PubMed:12083483, ECO:0000269|PubMed:12353082, ECO:0000269|PubMed:1371279, ECO:0000269|PubMed:1438206, ECO:0000269|PubMed:15583747, ECO:0000269|PubMed:15634267, ECO:0000269|PubMed:15748237, ECO:0000269|PubMed:1602006, ECO:0000269|PubMed:20020534, ECO:0000269|PubMed:2392682, ECO:0000269|PubMed:8781422, ECO:0000269|PubMed:9215749, ECO:0000269|PubMed:9376589, ECO:0000269|PubMed:9684783, ECO:0000269|PubMed:9790984}. Note=The disease is caused by mutations affecting the gene represented in this entry.; DISEASE: Bleeding disorder, platelet-type 16 (BDPLT16) [MIM:187800]: An autosomal dominant form of congenital macrothrombocytopenia associated with platelet anisocytosis. It is a disorder of platelet production. Affected individuals may have no or only mildly increased bleeding tendency. In vitro studies show mild platelet functional abnormalities. {ECO:0000269|PubMed:18065693}. Note=The disease is caused by mutations affecting the gene represented in this entry.
相似的序列: Belongs to the integrin beta chain family. {ECO:0000305}.; Contains 1 VWFA domain. {ECO:0000305}.
General information above from UniProt

CD61/Integrin beta 3/ITGB3 別稱

GT,BDPLT2,BDPLT16,CD61,GP3A,GPIIIa, [homo-sapiens]
CD61,GP3A,INGRB3, [mus-musculus]

CD61/Integrin beta 3/ITGB3 相關文獻

請注意:所有產品都是“僅用於科研,而不能用於診斷或治療用途”