CD51 & ITGB6 Heterodimer (Protein | Antibody | cDNA Clone | ELISA Kit)

All CD51 & ITGB6 Heterodimer reagents are produced in house and quality controlled, including 2 CD51 & ITGB6 Heterodimer Antibody, 2 CD51 & ITGB6 Heterodimer Lysate, 2 CD51 & ITGB6 Heterodimer Protein. All CD51 & ITGB6 Heterodimer reagents are ready to use.

CD51 & ITGB6 Heterodimer Protein (2)

CD51 & ITGB6 Heterodimer Antibody (2)

CD51 & ITGB6 Heterodimer Lysate (2)

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CD51 & ITGB6 Heterodimer Background

Integrin alpha-5, also known as ITGA5, is a single-pass type I membrane protein which belongs to theintegrin alpha chain family. ITGA5 contains 7FG-GAP repeats. Alpha chain 5 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form a fibronectin receptor. ITGAV&ITGB6 is a receptor for fibronectin and cytotactin. It recognizes the sequence R-G-D in its ligands. Internalisation of ITGAV&ITGB6 via clathrin-mediated endocytosis promotes carcinoma cell invasion.

CD51 & ITGB6 Heterodimer References

  • Suzuki S., et al.,(1987), Amino acid sequence of the vitronectin receptor alpha subunit and comparative expression of adhesion receptor mRNAs. J. Biol. Chem. 262:14080-14085.
  • Sims M.A., et al., (2000), Cloning and characterisation of ITGAV, the genomic sequence for human cell adhesion protein (vitronectin) receptor alpha subunit, CD51.Cytogenet. Cell Genet. 89:268-271.
  • Ota T., et al.,(2004), Complete sequencing and characterization of 21,243 full-length human cDNAs.Nat. Genet. 36:40-45.