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LILRB2/ILT4/LIR-2  Protein, Antibody, ELISA Kit, cDNA Clone

描述: Active  
表達宿主: Human Cells  
  • Slide 1
14132-H08H-50
14132-H08H-20
50 µg 
20 µg 
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表達宿主: Human Cells  
  • Slide 1
14132-H02H-50
14132-H02H-100
50 µg 
100 µg 
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LILRB2/ILT4/LIR-2 相关研究领域

LILRB2/ILT4/LIR-2 相關信號通路

    LILRB2/ILT4/LIR-2 概述&蛋白信息

    LILRB2/ILT4/LIR-2 研究背景

    亞單位結構: Binds PTPN6 when phosphorylated. Binds FCGR1A.
    結構域: Contains 3 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
    亞細胞定位: Membrane; Single-pass type I membrane protein.
    組織特異性: Expressed on monocytes and B-cells, and at lower levels on dendritic cells. Detected at low levels in natural killer (NK) cells. {ECO:0000269|PubMed:9548455, ECO:0000269|PubMed:9842885}.
    翻譯後修飾: Phosphorylated on tyrosine residues. Dephosphorylated by PTPN6. {ECO:0000269|PubMed:9842885}.
    相似的序列: Contains 4 Ig-like C2-type (immunoglobulin-like) domains. {ECO:0000305}.
    General information above from UniProt

    ILT4, also known as LILRB2, is a member of the the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). ILT4 gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family. Multiple transcript variants encoding different isoforms have been found for ILT4 gene. ILT4 is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity.

    LILRB2/ILT4/LIR-2 別稱

    LILRB2/ILT4/LIR-2 相關文獻

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