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人 IL29 / IFNL1 蛋白

產品資料評論相關產品實驗方法
Human IFNL1 蛋白產品資訊
分子別稱:IFNL1,IL-29,IL29
蛋白構建:A DNA sequence encoding the human IFNL1 (NP_742152.1) (Met1-Thr200) was expressed with an initial Met.
分子種屬:Human
表達宿主:Human Cells
#N/A:In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Human IFNL1 蛋白質控檢測
純度:> (80.7+15.8) % as determined by SDS-PAGE.
生物活性:Measured in antiviral assays using HepG2 cells infected with vesicular stomatitis virus.
The ED50 for this effect is typically 10-39 ng/mL.
內毒素:<1.0 EU per μg protein as determined by the LAL method.
穩定性:Samples are stable for up to twelve months from date of receipt at -70℃
預測N端:Met
分子量:The recombinant human IFNL1 consists 182 amino acids and predicts a molecular mass of 20.2 kDa.
緩衝液:Lyophilized from sterile PBS, pH 7.4.
1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
2. Please contact us for any concerns or special requirements.
Human IFNL1 蛋白使用指導
儲存方法:Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
#N/A:A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
Human IFNL1 Protein SDS-PAGE
Human IL29 / IFNL1 Protein SDS-PAGE

IFNL1 相關信號通路

    Other IFNL1 Recombinant Protein Products
    IL-29 研究背景

    Interleukin-29(IL-29), also known as cytokine Zcyto21, Interferon lambda-1, IFN-lambda-1, and IFNL1, is a secreted protein which belongs to the IL-28 / IL-29 family. IL-29 is a cytokine with immunomodulatory activity. IL-29 is highly similar in amino acid sequence to the IL-28. IL-28 and IL-29 are induced by viral infection and showed antiviral activity. IL-28 and IL-29 interacted with a heterodimeric class II cytokine receptor that consisted of IL-10 receptor beta (IL-10Rbeta) and an orphan class II receptor chain, designated IL-28Ralpha. IL-29 plays an important role in host defenses against microbes and its gene is highly upregulated in cells infected with viruses. IL-29 may play a role in antiviral immunity. IL-29 up-regulates MHC class I antigen expression. It is a Ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IL28RA. The ligand / receptor complex seems to signal through the Jak-STAT pathway.

    Human IL-29 參考資料
  • Li MC, et al. (2006) Liposome-mediated IL-28 and IL-29 expression in A549 cells and anti-viral effect of IL-28 and IL-29 on WISH cells. Acta Pharmacol Sin. 27(4): 453-9.
  • Wang J, et al. (2009) Differentiated human alveolar type II cells secrete antiviral IL-29 (IFN-lambda 1) in response to influenza A infection. J Immunol. 182(3): 1296-304.
  • Jordan WJ, et al. (2007) Modulation of the human cytokine response by interferon lambda-1 (IFN-lambda1/IL-29). Genes Immun. 8(1): 13-20.
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    貨號: 12339-HNAH-50
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    • Human IL29 / IFNL1 Protein SDS-PAGE
      All information of our products is subject to change without notice. Please refer to COA enclosed in shipped package for the newest information.
      請注意:所有產品都是“僅用於科研,而不能用於診斷或治療用途”