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IL32  Protein, Antibody, ELISA Kit, cDNA Clone

表達宿主: Human Cells  
11064-H08H-50
11064-H08H-100
50 µg 
100 µg 
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IL32 相关研究领域

IL32 相關信號通路

    IL32 相關蛋白、抗體、cDNA基因、ELISA試劑盒

    IL32 相關蛋白、抗體、cDNA基因、ELISA試劑盒

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    IL32 概述&蛋白信息

    IL32 研究背景

    基因概述: This IL32 gene encodes a member of the cytokine family. The IL-32 alpha protein contains a tyrosine sulfation site, 3 potential N-myristoylation sites, multiple putative phosphorylation sites, and an RGD cell-attachment sequence. Expression of this IL-32 alpha protein is increased after the activation of T-cells by mitogens or the activation of NK cells by IL-2. This protein induces the production of TNFalpha from macrophage cells. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
    General information above from NCBI
    亞細胞定位: Secreted {ECO:0000269|PubMed:15664165}.
    組織特異性: Selectively expressed in lymphocytes. Expression is more prominent in immune cells than in non-immune cells. {ECO:0000269|PubMed:15664165}.
    誘導: Expression increased after activation of T-cells by mitogens or activation of NK cells by IL2/interleukin-2. {ECO:0000269|PubMed:1729377}.

    IL-32 is a recently discovered cytokine that induces various proinflammatory cytokines (TNF-alpha, IL-1beta, IL-6) and chemokines in both human and mouse cells through the NF-kappaB and p38 MAPK inflammatory signal pathways. It is regulated robustly by other major proinflammatory cytokines, and is crucial to inflammation and immune responses. Four of the IL-32 isoforms (alpha, beta, gamma and delta) are the most representative IL-32 transcripts, and gamma isoform of IL-32 is the most active, although all isoforms are biologically active. IL-32, a cytokine produced mainly by T, natural killer, and epithelial cells induces significant amounts of TNFalpha and MIP-2 and increases the production of both cytokines in a dose-dependent manner. IL-32 has been implicated in inflammatory disorders, mycobacterium tuberculosis infections, inflammatory bowel disease, and influenza A virus infection, as well as in some autoimmune diseases, such as rheumatoid arthritis, ulcerative colitis and in human stomach cancer, human lung cancer and breast cancer tissues. Thus, IL-32 expression might be valuable as a biomarker for cancer.

    IL32 別稱

    IL32 相關文獻

  • Felaco P, et al. (2009) IL-32: a newly-discovered proinflammatory cytokine. J Biol Regul Homeost Agents. 23(3): 141-7.
  • Kobayashi H, et al. (2009) Molecular characterization of IL-32 in human endothelial cells. Cytokine. 46(3): 351-8.
  • Meyer N, et al. (2010) IL-32 is expressed by human primary keratinocytes and modulates keratinocyte apoptosis in atopic dermatitis. J Allergy Clin Immunol. 125(4): 858-865.
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