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IL2/IL-2/Interleukin-2  Protein, Antibody, ELISA Kit, cDNA Clone

描述:   
表達宿主: Yeast  
11848-HNAY1-50
11848-HNAY1-20
50 µg 
20 µg 
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  • Slide 1
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表達宿主: E. coli  
51061-MNAE-50
51061-MNAE-20
51061-MNAE-100
50 µg 
20 µg 
100 µg 
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  • Slide 1
描述: Active  
表達宿主: E. coli  
80075-RNAE-50
80075-RNAE-5
80075-RNAE-100
50 µg 
5 µg 
100 µg 
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  • Slide 1
描述: Active  
表達宿主: E. coli  
70014-DNAE-50
70014-DNAE-20
50 µg 
20 µg 
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  • Slide 1

IL2/IL-2/Interleukin-2 相关研究领域

IL2/IL-2/Interleukin-2 相關蛋白、抗體、cDNA基因、ELISA試劑盒

IL2/IL-2/Interleukin-2 概述&蛋白信息

IL2/IL-2/Interleukin-2 研究背景

基因概述: The Interleukin 2 protein encoded by this IL2 gene is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this IL2 gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this IL2 gene in the immune response to antigenic stimuli.
General information above from NCBI
亞細胞定位: Secreted.
相關疾病 : DISEASE: Note=A chromosomal aberration involving IL2 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with involves TNFRSF17.
相似的序列: Belongs to the IL-2 family. {ECO:0000305}.
General information above from UniProt

Interleukin-2, also known as T-cell growth factor, TCGF, Aldesleukin and IL2, is a secreted protein which belongs to the IL-2 family. Interleukin-2 / IL-2 was the first interleukin molecule to be discovered. Interleukin-2 / IL-2 molecule was first purified to homogeneity by immunoaffinity chromatography by Kendall Smith and his team at Dartmouth Medical School. Interleukin-2 / IL-2 was also the first cytokine shown to mediate its effects via a specific IL-2 receptor, and it was also the first interleukin to be cloned and expressed from a complementary DNA (cDNA) library. Interleukin-2 / IL-2 was designated number 2 because Smith's data at the time indicated that IL-1, produced by macrophages, facilitates IL-2 production by T lymphocytes (T cells).
Interleukin-2 / IL-2 is produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Interleukin-2 / IL-2 is normally produced by the body during an immune response. When environmental substances (molecules or microbes) gain access to the body, these substances (termed antigens) are recognized as foreign by antigen receptors that are expressed on the surface of lymphocytes. Antigen binding to the T cell receptor (TCR) stimulates the secretion of Interleukin-2 / IL-2, and the expression of IL-2 receptors IL-2R. The IL-2 / IL-2R interaction then stimulates the growth, differentiation and survival of antigen-selected cytotoxic T cells via the activation of the expression of specific genes. Interleukin-2 / IL-2 can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells. The World Reference Standard for Interleukin-2 / IL-2 is produced by the National Institute of Biological Standards and Control in the UK. A recombinant form of Interleukin-2 / IL-2 for clinical use is manufactured by Chiron Corporation with the brand name Proleukin. It has been approved by the Food and Drug Administration (FDA) for the treatment of cancers (malignant melanoma, renal cell cancer), and is in clinical trials for the treatment of chronic viral infections, and as a booster (adjuvant) for vaccines. The use of Interleukin-2 / IL-2 in HIV therapy has been found to be ineffective.

Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

IL2/IL-2/Interleukin-2 別稱

Interleukin-2, []
IL2,IL-2,lymphokine,TCGF, [human]
Il2,IL-2,TCGF,DN-144H19.3, [mouse]

IL2/IL-2/Interleukin-2 相關文獻

  • Smith KA, et al.,1980,  J. Exp. Med.151 (6): 1551-6. 
  • Smith KA, et al.,1980, Nature. 287 (5785): 853-5.
  • Taniguchi T, et al.,1983, Nature. 302 (5906): 305.
  • Cantrell DA, et al.,1984, Science. 224 (4655): 1312-6. 
  • Smith KA, et al.,1988, Science. 240 (4856): 1169-76.
  • Wang X. et al., 2005, Science 310:1159-63.
  • Stauber D.J. et al., 2006, Proc. Natl. Acad. Sci. USA. 103: 2788-93.
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