IL1R2 Matched ELISA Antibody Pair Set,Human

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IL1R2 Matched ELISA Antibody Pair Set,Human General Information

Product name
IL1R2 Matched ELISA Antibody Pair Set,Human
Assay type
Solid Phase Sandwich ELISA
Specificity
Quantitative determination of Human IL1R2
Assay range
9.38-600 pg/mL
Materials provided
1. Capture Antibody 0.5 mg/mL of rabbit anti-IL1R2 monoclonal antibody. Dilute to a working concentration of 2.0 μg/mL in CBS before coating (Catalog: # 10111-R041)
2. Detection Antibody 0.5 mg/mL mouse anti-IL1R2 monoclonal antibody conjugated to horseradish-peroxidase (HRP). Dilute to working concentration of 1.0 μg/mL in detection antibody dilution buffer before use. (Catalog: # 10111-MM02)
3. Standard Each vial contains 24 ng of recombinant IL1R2. Reconstitute with 1 mL detection antibody dilution buffer. After reconstitution, store at -20℃ to -80℃ in a manual defrost freezer. A seven-point standard curve usi ng 2-fold serial dilutions in sample dilution buffer, and a high standard of 600 pg/mL is recommended.
Product overview
This IL1R2 Matched ELISA Antibody Pair Set,Human is a solid phase sandwich ELISA for quantitative determination of Human IL1R2 . It contains Human IL1R2 capture antibody, Human IL1R2 detector antibody (HRP) and a highly purified HEK293-expressed recombinant Human IL1R2 protein. This Pair Set is at affordable price for researchers.
Shipping
This Matched ELISA Antibody Pair Set is shipped at ambient temperature.
Storage
Capture Antibody: Aliquot and store at -20℃ to -80℃ for up to 6 months from date of receipt. Avoid repeated freeze-thaw cycles.
Detection Antibody: Protect it from prolonged exposure to light. Aliquot and store at -20℃ to -80℃ and for up to 6 months from date of receipt. Avoid repeated freeze-thaw cycles.
Standard: Store lyophilized standard at -20℃ to -80℃ for up to 6 months from date of receipt. Aliquot and store the reconstituted Standard at -80℃ for up to 1 month. Avoid repeated freeze-thaw cycles.

IL1R2 Matched ELISA Antibody Pair Set,Human Images

IL1R2 Matched ELISA Antibody Pair Set,Human: Alternative Names

CD121b Matched ELISA Antibody Pair Set, Human; CDw121b Matched ELISA Antibody Pair Set, Human; IL-1R-2 Matched ELISA Antibody Pair Set, Human; IL-1RT-2 Matched ELISA Antibody Pair Set, Human; IL-1RT2 Matched ELISA Antibody Pair Set, Human; IL1R2c Matched ELISA Antibody Pair Set, Human; IL1RB Matched ELISA Antibody Pair Set, Human

IL1R2 Background Information

Interleukin 1 receptor, type II (IL1R2) also known as CD121b (Cluster of Differentiation 121b) is a cytokine receptor that belongs to the interleukin-1 receptor family. This protein binds interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I (IL1R1/IL1RA), and acts as a decoy receptor that inhibits the activity of its ligands. The pleiotropic cytokine IL1 is produced to regulate development and maintenance of the inflammatory responses, and binds to specific plasma membrane receptors on cells. Two distinct types of IL1 receptors which are able to bind IL1 specifically have been identified, designated as IL1RI (IL1RA) and IL1RII (IL1RB). IL1R1 contributes to IL-1 signaling, whereas the IL-1R2/CD121b has no signaling property and acts as a decoy for IL-1. IL-1R2/CD121b structurally consisting of a ligand binding portion comprised of three Ig-like domains, a single transmembrane region, and a short cytoplasmic domain, is expressed in a variety of cell types including B lymphocytes, neutrophils, monocytes, large granular leukocytes and endothelial cells. Interleukin 4 (IL4) is reported to antagonize the activity of interleukin 1 by inducing the expression and release of this cytokine.
Full Name
interleukin 1 receptor, type II
References
  • Cannon JG, et al. (1997) Interleukin-1 beta, interleukin-1 receptor antagonist, and soluble interleukin-1 receptor type II secretion in chronic fatigue syndrome. J Clin Immunol. 17 (3): 253-61.
  • Liu C, et al. (1996) Cloning and characterization of an alternatively processed human type II interleukin-1 receptor mRNA. J Biol Chem. 271 (34): 20965-72.
  • Van der Poll T, et al. (1997) Antiinflammatory cytokine responses during clinical sepsis and experimental endotoxemia: sequential measurements of plasma soluble interleukin (IL)-1 receptor type II, IL-10, and IL-13. J Infect Dis. 175 (1): 118-22.
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