IL-18 (Protein|Antibody|cDNA Clone|ELISA Kit)

All IL-18 reagents are produced in house and quality controlled, including 13 IL-18 Antibody, 4 IL-18 ELISA, 65 IL-18 Gene, 2 IL-18 IPKit, 4 IL-18 Protein, 3 IL-18 qPCR. All IL-18 reagents are ready to use.

Recombinant IL-18 proteins are expressed by E. coli with fusion tags as N-GST, Native, N-cleavage, N-His.

IL-18antibodies are validated with different applications, which are WB, ELISA, IP, ELISA(Det), ELISA(Cap).

IL-18cDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each IL-18 of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.

IL-18ELISA Kit are quality controlled by 8 internation QC standard which guarantee every ELISA Kit with high quality.

IL-18 Protein (4)

Species

IL-18 Protein, Human, Recombinant

10119-HNCE

Expression host: E. coli

Human IL18/IL-18/Interleukin 18 Protein 8417

IL-18 Protein, Rhesus, Recombinant (His Tag)

90011-C07E

Expression host: E. coli

Rhesus IL18/IL-18/Interleukin 18 Protein 12722

IL-18 Protein, Mouse, Recombinant

50073-MNCE

Expression host: E. coli

Mouse IL18/IL-18/Interleukin 18 Protein 11368
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IL-18 Antibody (13)

Application Clonality
Host

Anti-IL-18 Antibody

50073-R169

Application: ELISA(Cap)

Clonality: MAb

Anti-IL-18 Antibody

50073-T16

Application: ELISA

Clonality: PAb

Anti-IL-18 Antibody

90011-MM02

Application: ELISA

Clonality: MAb

Anti-IL-18 Antibody

90011-RP02

Application: WB,IP

Clonality: PAb

Cynomolgus IL18/IL-18/Interleukin 18 Immunoprecipitation(IP) 6107

Anti-IL-18 Antibody

10119-R011

Application: ELISA,ELISA(Cap)

Clonality: MAb

Anti-IL-18 Antibody

50073-RP01

Application: ELISA

Clonality: PAb

Anti-IL-18 Antibody

10119-MM15

Application: ELISA

Clonality: MAb

Anti-IL-18 Antibody

10119-T16

Application: ELISA

Clonality: PAb

Anti-IL-18 Antibody

50073-R167

Application: ELISA,ELISA(Det)

Clonality: MAb

Anti-IL-18 Antibody

50073-T48

Application: WB,ELISA

Clonality: PAb

Mouse IL18/IL-18/Interleukin 18 Western blot (WB) 17829

Anti-IL-18 Antibody

10119-T52

Application: WB,ELISA,IP

Clonality: PAb

Human IL18/IL-18/Interleukin 18 Western blot (WB) 6564

Anti-IL-18 Antibody

90011-MM17

Application: ELISA

Clonality: MAb

Anti-IL-18 Antibody

90011-RP01

Application: ELISA

Clonality: PAb

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IL-18 ELISA KIT & match antibody elias pair set ( 4 )

IL-18 Matched ELISA Antibody Pair Set,Human

SEK10119

Assay Range: 31.25 pg/ml

Human IL18/IL-18/Interleukin 18 ELISA Pair Set Standard Curve 18452

IL-18 ELISA Kit, Mouse

KIT50073

Sensitivity: 21.03 pg/mL

Mouse IL18/IL-18/Interleukin 18 ELISA Kit Standard Curve 123

IL-18 Matched ELISA Antibody Pair Set,Mouse

SEK50073

Assay Range: 23.44 pg/ml

Mouse IL18/IL-18/Interleukin 18 ELISA Pair Set Standard Curve 13979

IL-18 ELISA Kit, Human

KIT10119

Sensitivity: 22.88 pg/mL

Human HPGD/15-PGDH ELISA Kit Standard Curve 18698

IL-18 cDNA Clone (65)

Rhesus
Canine
Human
Mouse
Rat

IL-18 qPCR Primer (3)

IL-18 IP Kit (2)

Interleukin-18 (IL-18, also known as interferon-gamma inducing factor) is a proinflammatory cytokine that belongs to the IL-1 superfamily and is produced by macrophages and other cells. This cytokine can induce the IFN-gamma production of T cells. The combination of IL-18 and IL12 has been shown to inhibit IL4 dependent IgE and IgG1 production, and enhance IgG2a production of B cells. IL-18 binding protein (IL18BP) can specifically interact with this cytokine, and thus negatively regulate its biological activity. IL-18 is an IL-1−like cytokine that requires cleavage with caspase-1 to become active, was found to increase IgE production in a CD4+ T cells-, IL-4− and STAT6−dependent fashion. IL-18 and T cell receptor−mediated stimulation could induce naïve CD4+ T cells to develop into IL-4−producing cells in vitro. Thus, caspase-1 and IL-18 may be critical in regulation of IgE production in vivo, providing a potential therapeutic target for allergic disorders. IL-18 production in primary synovial cultures and purified synovial fibroblasts was, in turn, upregulated by TNF-α and IL-1β, suggesting that monokine expression can feed back to promote Th1 cell development in synovial membrane. Besides, synergistic combinations of IL-18, IL-12, and IL-15 may be of importance in sustaining both Th1 responses and monokine production in RA.

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