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IL1A/IL-1A/IL-1F1  Protein, Antibody, ELISA Kit, cDNA Clone

描述: Active  
表達宿主: Human Cells  
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10128-HNCH-100
10128-HNCH-5
10128-HNCH-20
100 µg 
5 µg 
20 µg 
Add to Cart
描述: Active  
表達宿主: E. coli  
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50114-MNAE-100
50114-MNAE-20
50114-MNAE-5
100 µg 
20 µg 
5 µg 
Add to Cart

IL1A/IL-1A/IL-1F1 相關信號通路

IL1A/IL-1A/IL-1F1 概述&蛋白信息

IL1A/IL-1A/IL-1F1 研究背景

基因概述: The IL-1 alpha protein encoded by this IL1A gene is a member of the interleukin 1 cytokine family. This cytokine is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. This IL-1 alpha cytokine is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury, and thus induces apoptosis. This IL1A gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. It has been suggested that the polymorphism of these genes is associated with rheumatoid arthritis and Alzheimer's disease.
General information above from NCBI
亞單位結構: Monomer.
結構域: The similarity among the IL-1 precursors suggests that the amino ends of these proteins serve some as yet undefined function.
亞細胞定位: Secreted. Note=The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins.
相似的序列: Belongs to the IL-1 family.
General information above from UniProt

IL-1 alpha is a member of the interleukin 1 cytokine family. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation and cell survival/apoptosis but are also involved in several pathophysiological processes including viral infections and autoimmune diseases. Cytokines are synthesized under various stimuli by a variety of cells of both the innate (monocytes, macrophages, dendritic cells) and adaptive (T- and B-cells) immune systems. Cytokines can be classified into two groups: pro- and anti-inflammatory. Pro-inflammatory cytokines, including IFNgamma, IL-1, IL-6 and TNF-alpha, are predominantly derived from the innate immune cells and Th1 cells. Anti-inflammatory cytokines, including IL-10, IL-4, IL-13 and IL-5, are synthesized from Th2 immune cells. IL-1 alpha is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. It is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury, and thus induces apoptosis. IL-1 alpha stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity.

IL1A/IL-1A/IL-1F1 別稱

IL1,IL-1A,IL1F1,IL1-ALPHA, [homo-sapiens]
IL1,IL-1 alpha,IL1A,IL-1A,IL1-ALPHA,IL1F1, [human]
Il-1a, [mus-musculus]

IL1A/IL-1A/IL-1F1 相關文獻

  • Nicklin MJ,et al. (1994) A physical map of the region encompassing the human interleukin-1 alpha, interleukin-1 beta, and interleukin-1 receptor antagonist genes. Genomics. 19(2):382-4.
  • March CJ, et al. (1985) Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs. Nature. 315(6021):641-7.
  • Bankers-Fulbright JL, et al. (1996) Interleukin-1 signal transduction. Life Sci. 59(2):61-83.
  • Dinarello CA, et al. (1997) Induction of interleukin-1 and interleukin-1 receptor antagonist. Semin Oncol. 24 (3 Suppl 9):S9-81-S9-93.
  • 請注意:所有產品都是“僅用於科研,而不能用於診斷或治療用途”