Text Size:AAA

ICOS/AILIM/CD278  Protein, Antibody, ELISA Kit, cDNA Clone

描述: Active  
表達宿主: Human Cells  
50 µg 
100 µg 
Add to Cart
  • Slide 1
表達宿主: Human Cells  
200 µg 
100 µg 
Add to Cart
  • Slide 1
表達宿主: Human Cells  
50 µg 
100 µg 
Add to Cart
  • Slide 1

ICOS/AILIM/CD278 相关研究领域

ICOS/AILIM/CD278 相關信號通路

    ICOS/AILIM/CD278 相關蛋白、抗體、cDNA基因、ELISA試劑盒

    ICOS/AILIM/CD278 相關蛋白、抗體、cDNA基因、ELISA試劑盒

    Featured Reagent Products

    ICOS/AILIM/CD278 概述&蛋白信息

    ICOS/AILIM/CD278 研究背景

    基因概述: The protein encoded by this ICOS gene belongs to the CD28 and CTLA-4 cell-surface receptor family. CD278 forms homodimers and plays an important role in cell-cell signaling, immune responses, and regulation of cell proliferation. [provided by RefSeq, Jul 2008]
    General information above from NCBI
    亞單位結構: Homodimer; disulfide-linked. {ECO:0000269|PubMed:11169414, ECO:0000269|PubMed:9930702}.
    亞細胞定位: Isoform 1: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.; Isoform 2: Secreted {ECO:0000305}.
    組織特異性: Activated T-cells. Highly expressed on tonsillar T-cells, which are closely associated with B-cells in the apical light zone of germinal centers, the site of terminal B-cell maturation. Expressed at lower levels in thymus, lung, lymph node and peripheral blood leukocytes. Expressed in the medulla of fetal and newborn thymus. {ECO:0000269|PubMed:11006126, ECO:0000269|PubMed:11169414, ECO:0000269|PubMed:9930702}.
    誘導: By phorbol myristate acetate (PMA) and ionomycin. Up-regulated early on T-cells and continues to be expressed into the later phases of T-cell activation. {ECO:0000269|PubMed:11169414}.
    翻譯後修飾: N-glycosylated. {ECO:0000269|PubMed:11169414}.
    相關疾病 : DISEASE: Immunodeficiency, common variable, 1 (CVID1) [MIM:607594]: A primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low. {ECO:0000269|PubMed:12577056}. Note=The disease is caused by mutations affecting the gene represented in this entry.
    相似的序列: Contains 1 Ig-like V-type (immunoglobulin-like) domain. {ECO:0000305}.
    General information above from UniProt

    Inducible costimulator (ICOS), also called AILIM (activiation-inducible lymphocyte immunomediatory molecule) is a cell-surface receptor, and belongs to the CD28 family of immune costimulatory receptors consisting of CD28, CTLA-4 and PD-1. The interaction of B7-H2/ICOS plays a critical role in Th cell differentiation, T−B cell interactions which is essential for germinal center formation, and humoral immune responses, and as well as the production of cytokine IL-4. In addition, ICOS is more potent in the induction of IL-10 production, a cytokine important for suppressive function of T regulatory cells. The B7-1/B7-2--CD28/CTLA-4 and ICOS-B7RP-1 pathway provides key second signals that can regulate the activation, inhibition and fine-tuning of T-lymphocyte responses. ICOS stimulates both Th1 and Th2 cytokine production but may have a preferential role in Th2 cell development. Moreover, The B7-1/B7-2-CD28/CTLA-4 and ICOS-B7RP-1 pathway has been suggested of being involved in the development of airway inflammation and airway hyperresponsiveness.

    Immune Checkpoint
    Immune Checkpoint Proteins
    Immune Checkpoint Targets   Co-stimulatory Immune Checkpoint Targets

    Immunotherapy   Cancer Immunotherapy   Targeted Therapy

    ICOS/AILIM/CD278 別稱

    CVID1 , []
    AILIM,CD278,CVID1, [homo-sapiens]
    AILIM,CD278,ICOS,MGC39850, [human]
    AILIM,CCLP,CH29-120A16.4,CRP-1,H4,Icos,Ly115, [mouse]
    CCLP,AILIM,CRP-1,Ly115,H4, [mus-musculus]

    ICOS/AILIM/CD278 相關文獻

  • Coyle AJ, et al. (2004) The role of ICOS and other costimulatory molecules in allergy and asthma. Springer Semin Immunopathol. 25(3-4): 349-59.
  • Chen YQ, et al. (2006) CD28/CTLA-4--CD80/CD86 and ICOS--B7RP-1 costimulatory pathway in bronchial asthma. Allergy. 61(1): 15-26.
  • van Berkel ME, et al. (2006) CD28 and ICOS: similar or separate costimulators of T cells Immunol Lett. 105(2): 115-22.
  • 請注意:所有產品都是“僅用於科研,而不能用於診斷或治療用途”