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Human IL-1 beta / IL1B Protein

  • Human IL1B/IL-1B/IL-1 beta Protein 14962
產品資料評論相關產品實驗方法
 IL1B 蛋白產品資訊
分子別稱:IL-1,IL-1 beta,IL-1B,IL1-BETA,IL1F2
蛋白構建:A DNA sequence encoding the mature form of human IL1B (NP_000567.1) (Ala 117-Ser 269) was expressed with a N-terminal Met.
分子種屬:Human
表達宿主:E. coli
#N/A:In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
 IL1B 蛋白質控檢測
純度:> 95 % as determined by SDS-PAGE.
內毒素:< 10 EU per mg of the protein as determined by the LAL method
穩定性:Samples are stable for up to twelve months from date of receipt at -70℃
預測N端:Met
分子量:The recombinant human IL1B consists of 154 amino acids and predicts a molecular mass of 17.5 kDa
緩衝液:Lyophilized from sterile PBS, pH 7.4
1. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
2. Please contact us for any concerns or special requirements.
 IL1B 蛋白使用指導
儲存方法:Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
#N/A:A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

IL1B 相關信號通路

    Other IL1B Recombinant Protein Products
    IL1B/IL-1B/IL-1 beta 研究背景

    Interleukin-1 beta (IL1 beta or IL1B) also known as catabolin, is a member of the interleukin 1 cytokine family. IL1 is a pleiotropic cytokine. It is involved in the inflammatory response, cell growth, and tissue repair in the cortex. The IL1 superfamily consists of three members, IL1A (IL1 alpha), IL1B (IL1 beta), and IL1 receptor antagonist (IL1Ra). In clinical, it has been reported that Interleukin (IL)-1 may influence Th1 / Th2 immune responsiveness and has been implicated in the establishment of successful pregnancy. Proinflammatory interleukin (IL)-1 gene polymorphisms associated with high levels of IL-1beta activity increase the risk for hypochlorhydria and distal gastric carcinoma. IL1B polymorphisms may be involved in susceptibility to SSc. Moreover, the IL2-384-G allele may be a marker for the limited phenotype of systemic sclerosis (SSc).

    Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

     IL1B/IL-1B/IL-1 beta 參考資料
  • Kim SH, et al. (2008) Association of -31TC and -511 CT polymorphisms in the interleukin 1 beta (IL1B) promoter in Korean keratoconus patients. Mol Vis. 14:2109-16.
  • Wang ZC, et al. (2002) T helper 1-type immunity to trophoblast antigens in women with a history of recurrent pregnancy loss is associated with polymorphism of the IL1B promoter region. Genes Immun. 3(1): 38-42.
  • Mattuzzi S, et al. (2007) Association of polymorphisms in the IL1B and IL2 genes with susceptibility and severity of systemic sclerosis. J Rheumatol. 34(5): 997-1004.
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    貨號: GMP-10139-HNAE-20
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    Datasheet & Documentation

    Contact Us
    All information of our products is subject to change without notice. Please refer to COA enclosed in shipped package for the newest information.
    請注意:所有產品都是“僅用於科研,而不能用於診斷或治療用途”