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Coronavirus  Nucleoprotein

Coronavirus  Nucleoprotein 蛋白和抗體

NP-CoV 蛋白NP-CoV 抗體NP-CoV 基因NP-CoV 

Coronavirus Nucleoprotein 背景

Coronaviruses are enveloped viruses with a positive-sense RNA genome and with a nucleocapsid of helical symmetry. Proteins that contribute to the overall structure of all coronaviruses are the spike (S), envelope (E), membrane (M) and nucleocapsid (N). Coronavirus N protein is required for coronavirus RNA synthesis, and has RNA chaperone activity that may be involved in template switch. Coronaviruses primarily infect the upper respiratory and gastrointestinal tract of mammals and birds.Coronavirus symptoms include rhinorrhea, sneezing, cough, nasal obstruction, bronchitis and so on. In 2003, a novel coronavirus which is known as SARS coronavirus cause the severe acute respiratory syndrome (SARS) epidemic that began in Asia in 2002. As a novel coronavirus, human betacoronavirus 2c's isolation and genome sequencing were reported in June 2012. Genome sequencing showed that human betacoronavirus 2c belongs to the group C species of the genus betacoronavirus and phylogenetically related to the bat coronaviruses HKU4 and HKU5 previously found in lesser bamboo bat and Japanese Pipistrelle bat of Hong Kong respectively.

Coronavirus Nucleoprotein 參考文獻

  1. Van Boheemen S, et al. (2012) Genomic Characterization of a Newly Discovered Coronavirus Associated with Acute Respiratory Distress Syndrome in Humans. MBio. 3(6):e00473-12.
  2. Li F, et al. (2005) Evidence for a Common Evolutionary Origin of Coronavirus Spike Protein Receptor-Binding Subunits. Science. 309(5742):1864-8.
  3. Chan JF, et al. (2012) Is the discovery of the novel human betacoronavirus 2c EMC/2012 (HCoV-EMC) the beginning of another SARS-like pandemic?. J Infect. 65(6):477-89.
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