**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**
Cytotoxic T-lymphocyte protein 4, also known as CTLA4 and CD152, is a single-pass type I membrane protein and a member of the immunoglobulin superfamily. It is the second member of the CD28 receptor family. The ligands or counterreceptors for these two proteins are the B7 family members, CD80 (B7-1) and CD86 (B7-2). CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found in regulatory T cells and may play an important role in their functions. CD152 or cytotoxic T lymphocyte antigen-4 (CTLA-4) is an essential receptor involved in the negative regulation of T cell activation. Because of its profound inhibitory role, CD152 has been considered a sound susceptible candidate in autoimmunity and a persuasive target for cancer immunotherapy. In particular, recent evidence suggests that CD152 is also important in the homeostasis and function of a population of suppressive cells, termed regulatory T cells (Treg).
Immune Checkpoint
Immune Checkpoint Detection: Antibodies Immune Checkpoint Detection: ELISA Antibodies Immune Checkpoint Detection: IP Antibodies Immune Checkpoint Detection: WB Antibodies
Immune Checkpoint Proteins CTLA4 / CD152 Immune Checkpoint Proteins
Immune Checkpoint Targets Co-inhibitory Immune Checkpoint Targets
CTLA-4 cDNA ORF Clone, Canine, Related Products
| Product Name | Catalog#(PDF) |
|---|---|
| CTLA-4 cDNA ORF Clone in Cloning Vector, Canine | DG70113-G |
CTLA-4 cDNA ORF Clone, Rhesus, Related Products
| Product Name | Catalog#(PDF) |
|---|---|
| CTLA-4 cDNA ORF Clone, Rhesus, untagged | CG90213-UT |
| CTLA-4 Lentiviral cDNA ORF Clone, Rhesus, C-GFPSpark® tag | CG90213-ACGLN |
CTLA-4 cDNA ORF Clone, Rat, Related Products
| Product Name | Catalog#(PDF) |
|---|---|
| CTLA-4 cDNA ORF Clone in Cloning Vector, Rat | RG81069-G |
CTLA-4 cDNA ORF Clone, Mouse, Related Products
CTLA-4 cDNA ORF Clone, Human, Related Products
