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人 VCAM1/VCAM-1/CD106 transcript variant 1 基因全長cDNA ORF克隆 (表達載體), N-His 標籤

  • Human IL12A / IL-12A Gene Plasmid Map 5646
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 VCAM1 cDNA Clone產品資訊
註冊碼:NM_001078.2
cDNA基因長度:2241 bp
cDNA基因描述:Full length Clone DNA of Homo sapiens vascular cell adhesion molecule 1, transcript variant 1 with N terminal His tag.
基因別名:VCAM1, CD106, MGC99561, INCAM-100, DKFZp779G2333
分子種屬:Human
載體:pCMV3-SP-N-His
Plasmid:pCMV3-His-VCAM1
限制性酶切位點:KpnI + NotI(6kb+2.24kb)
Tag序列:His Tag Sequence: CACCATCACCACCATCATCACCACCATCAC
序列資訊:Identical with the Gene Bank Ref. ID sequence.
Sequencing primers:T7(TAATACGACTCACTATAGGG) BGH(TAGAAGGCACAGTCGAGG)
( We provide with VCAM1 qPCR primers for gene expression analysis, HP100188 )
Promoter:Enhanced CMV mammalian cell promoter
Application:Stable or Transient mammalian expression
Antibiotic in E.coli:Kanamycin
Antibiotic in mammalian cell:Hygromycin
運輸條件:Each tube contains lyophilized plasmid.
儲存方法:The lyophilized plasmid can be stored at room temperature for three months.
His Tag Info

A polyhistidine-tag is an amino acid motif in proteins that consists of at least five histidine (His) residues, often at the N- or C-terminus of the protein.

Polyhistidine-tags are often used for affinity purification of polyhistidine-tagged recombinant proteins expressed in Escherichia coli and other prokaryotic expression systems.

人 VCAM1/VCAM-1/CD106 transcript variant 1 基因全長cDNA ORF克隆 (表達載體), N-His 標籤 on other vectors
人 VCAM1/VCAM-1/CD106 transcript variant 1 基因全長cDNA ORF克隆 (表達載體), C-GFPSpark 標籤HG10113-ACGNT$8880
人 VCAM1/VCAM-1/CD106 transcript variant 1 基因全長cDNA ORF克隆 (表達載體), C-OFPSpark 標籤HG10113-ACRNT$8880
人 VCAM1/VCAM-1/CD106 transcript variant 1 基因全長cDNA ORF克隆 (表達載體), C-Flag 標籤HG10113-CFNT$7790
人 VCAM1/VCAM-1/CD106 transcript variant 1 基因全長cDNA ORF克隆 (表達載體), C-His 標籤HG10113-CHNT$7790
人 VCAM1/VCAM-1/CD106 transcript variant 1 基因全長cDNA ORF克隆 (表達載體), C-Myc 標籤HG10113-CMNT$7790
人 VCAM1/VCAM-1/CD106 transcript variant 1 基因全長cDNA ORF克隆 (表達載體), C-HA 標籤HG10113-CYNT$7790
人 VCAM1/VCAM-1/CD106 transcript variant 1 基因全長cDNA ORF(克隆載體)HG10113-MNT$2720
人 VCAM1/VCAM-1/CD106 transcript variant 1 基因全長cDNA ORF克隆 (表達載體)HG10113-M-NNT$7790
人 VCAM1/VCAM-1/CD106 transcript variant 1 基因全長cDNA ORF克隆 (表達載體), N-Flag 標籤HG10113-NFNT$7790
人 VCAM1/VCAM-1/CD106 transcript variant 1 基因全長cDNA ORF克隆 (表達載體), N-His 標籤HG10113-NHNT$7790
人 VCAM1/VCAM-1/CD106 transcript variant 1 基因全長cDNA ORF克隆 (表達載體), N-Myc 標籤HG10113-NMNT$7790
人 VCAM1/VCAM-1/CD106 transcript variant 1 基因全長cDNA ORF克隆 (表達載體), N-HA 標籤HG10113-NYNT$7790
人 VCAM1/VCAM-1/CD106 transcript variant 1 基因全長cDNA ORF克隆 (表達載體)HG10113-UTNT$7790
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研究背景

Vascular cell adhesion molecule 1 (VCAM-1), also known as CD106, is a cell surface sialoglycoprotein belonging to the immunoglobulin superfamily. Two forms of VCAM-1 with either six or seven extracellular Ig-like domains are generated by alternative splicing, with the longer form predominant. VCAM-1 is an endothelial ligand for very late antigen-4 (VLA-4) and α4ß7 integrin expressed on leukocytes, and thus mediates leukocyte-endothelial cell adhesion and signal transduction. VCAM-1 expression is induced on endothelial cells during inflammatory bowel disease, atherosclerosis, allograft rejection, infection, and asthmatic responses. During these responses, VCAM-1 forms a scaffold for leukocyte migration. VCAM-1 also activates signals within endothelial cells resulting in the opening of an "endothelial cell gate" through which leukocytes migrate. VCAM-1 has been identified as a potential anti-inflammatory therapeutic target, the hypothesis being that reduced expression of VCAM-1 will slow the development of atherosclerosis. In addition, VCAM-1-activated signals in endothelial cells are regulated by cytokines indicating that it is important to consider both endothelial cell adhesion molecule expression and function during inflammatory processes.

Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

參考資料
  • Cook-Mills JM. (2002) VCAM-1 signals during lymphocyte migration: role of reactive oxygen species. Mol Immunol. 39(9): 499-508.
  • Preiss DJ, et al. (2007) Vascular cell adhesion molecule-1: a viable therapeutic target for atherosclerosis? Int J Clin Pract. 61(4): 697-701.
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    貨號: HG10113-NH
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