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人 VCAM1/VCAM-1/CD106 transcript variant 1 基因全長cDNA ORF克隆 (表達載體), N-His 標籤

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Human VCAM1 cDNA Clone產品資訊
註冊碼:NM_001078.2
cDNA基因長度:2220bp
cDNA基因描述:Full length Clone DNA of Homo sapiens vascular cell adhesion molecule 1, transcript variant 1 with N terminal His tag.
基因別名:VCAM1, CD106, MGC99561, INCAM-100, DKFZp779G2333
分子種屬:Human
載體:pCMV3-SP-N-His
Plasmid:
限制性酶切位點:
Tag序列:His Tag Sequence: CACCATCACCACCATCATCACCACCATCAC
序列資訊:
Sequencing primers:T7(TAATACGACTCACTATAGGG) BGH(TAGAAGGCACAGTCGAGG)
Promoter:Enhanced CMV mammalian cell promoter
Application:Stable or Transient mammalian expression
Antibiotic in E.coli:Kanamycin
Antibiotic in mammalian cell:Hygromycin
運輸條件:Each tube contains lyophilized plasmid.
儲存方法:The lyophilized plasmid can be stored at room temperature for three months.
His Tag Info

A polyhistidine-tag is an amino acid motif in proteins that consists of at least five histidine (His) residues, often at the N- or C-terminus of the protein.

Polyhistidine-tags are often used for affinity purification of polyhistidine-tagged recombinant proteins expressed in Escherichia coli and other prokaryotic expression systems.

人 VCAM1/VCAM-1/CD106 transcript variant 1 基因全長cDNA ORF克隆 (表達載體), N-His 標籤 on other vectors
人 VCAM1/VCAM-1/CD106 transcript variant 1 基因全長cDNA ORF克隆 (表達載體), C-GFPSpark 標籤HG10113-ACGNT$8880
人 VCAM1/VCAM-1/CD106 transcript variant 1 基因全長cDNA ORF克隆 (表達載體), C-OFPSpark 標籤HG10113-ACRNT$8880
人 VCAM1/VCAM-1/CD106 transcript variant 1 基因全長cDNA ORF克隆 (表達載體), C-Flag 標籤HG10113-CFNT$7790
人 VCAM1/VCAM-1/CD106 transcript variant 1 基因全長cDNA ORF克隆 (表達載體), C-His 標籤HG10113-CHNT$7790
人 VCAM1/VCAM-1/CD106 transcript variant 1 基因全長cDNA ORF克隆 (表達載體), C-Myc 標籤HG10113-CMNT$7790
人 VCAM1/VCAM-1/CD106 transcript variant 1 基因全長cDNA ORF克隆 (表達載體), C-HA 標籤HG10113-CYNT$7790
人 VCAM1/VCAM-1/CD106 transcript variant 1 基因全長cDNA ORF(克隆載體)HG10113-MNT$2720
人 VCAM1/VCAM-1/CD106 transcript variant 1 基因全長cDNA ORF克隆 (表達載體)HG10113-M-NNT$7790
人 VCAM1/VCAM-1/CD106 transcript variant 1 基因全長cDNA ORF克隆 (表達載體), N-Flag 標籤HG10113-NFNT$7790
人 VCAM1/VCAM-1/CD106 transcript variant 1 基因全長cDNA ORF克隆 (表達載體), N-His 標籤HG10113-NHNT$7790
人 VCAM1/VCAM-1/CD106 transcript variant 1 基因全長cDNA ORF克隆 (表達載體), N-Myc 標籤HG10113-NMNT$7790
人 VCAM1/VCAM-1/CD106 transcript variant 1 基因全長cDNA ORF克隆 (表達載體), N-HA 標籤HG10113-NYNT$7790
人 VCAM1/VCAM-1/CD106 transcript variant 1 基因全長cDNA ORF克隆 (表達載體)HG10113-UTNT$7790
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研究背景

Vascular cell adhesion molecule 1 (VCAM-1), also known as CD106, is a cell surface sialoglycoprotein belonging to the immunoglobulin superfamily. Two forms of VCAM-1 with either six or seven extracellular Ig-like domains are generated by alternative splicing, with the longer form predominant. VCAM-1 is an endothelial ligand for very late antigen-4 (VLA-4) and α4ß7 integrin expressed on leukocytes, and thus mediates leukocyte-endothelial cell adhesion and signal transduction. VCAM-1 expression is induced on endothelial cells during inflammatory bowel disease, atherosclerosis, allograft rejection, infection, and asthmatic responses. During these responses, VCAM-1 forms a scaffold for leukocyte migration. VCAM-1 also activates signals within endothelial cells resulting in the opening of an "endothelial cell gate" through which leukocytes migrate. VCAM-1 has been identified as a potential anti-inflammatory therapeutic target, the hypothesis being that reduced expression of VCAM-1 will slow the development of atherosclerosis. In addition, VCAM-1-activated signals in endothelial cells are regulated by cytokines indicating that it is important to consider both endothelial cell adhesion molecule expression and function during inflammatory processes.

參考資料
  • Cook-Mills JM. (2002) VCAM-1 signals during lymphocyte migration: role of reactive oxygen species. Mol Immunol. 39(9): 499-508.
  • Preiss DJ, et al. (2007) Vascular cell adhesion molecule-1: a viable therapeutic target for atherosclerosis? Int J Clin Pract. 61(4): 697-701.
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    貨號: HG10113-NH
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