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Histone H3 抗體, 鼠單抗

  • Histone H3 Antibody, Mouse MAb, Immunoprecipitation
  • Histone H3 Antibody, Mouse Mab, Immunochemistry
  • Histone H3 Antibody, Mouse Mab, Immunochemistry
  • Histone H3 Antibody, Mouse MAb, Western blot
產品資料評論相關產品實驗方法
 Histone H3 抗體產品資訊
免疫原:A synthetic peptide corresponding to the C-terminus of the human Histone H3.
Clone ID:1F6D7C4
Ig類型:Mouse IgG2b
濃度:
內毒素:
緩衝液:0.2 μm filtered solution in PBS
抗體製備方法:This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with a synthetic peptide corresponding to the C-terminus of the human Histone H3. The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
 Histone H3 Antibody WB Application Image
 Histone H3 Antibody IHC Application Image
Histone H3 Antibody, Mouse Mab, Immunochemistry
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Caption:
Immunochemical staining of human histone H3 in human mammary gland with mouse monoclonal antibody (formalin-fixed paraffin embedded sections). Positive staining was localized to nucleus.
Histone H3 Antibody, Mouse Mab, Immunochemistry
[點擊查看大圖]
Caption:
Immunochemical staining of human histone H3 in human colon carcinoma with mouse monoclonal antibody (formalin-fixed paraffin embedded sections). Positive staining was localized to nucleus.
The left panel: tissue incubated with primary antibody;
The right panel: tissue incubated with the mixture of primary antibody and antigen (polypeptide).

 Histone H3 Antibody IP Application Image
Other Histone H3 Antibody Products
Histone H3 研究背景

Histone H3 is a histone protein. Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. They play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. Histone H3 is characterized by a main globular domain and a long N-terminal tail. It is involved with the structure of the nucleosomes of the 'beads on a string' structure. There are five main histone proteins involved in the structure of chromatin in eukaryotic cells. Histone H3 is the most extensively modified of the five histones. In the emerging field of epigenetics, it is thought that Histone H3 plays a key role, cause its sequence variants and variable modification states function in the dynamic and long term regulation of genes.

 Histone H3 參考資料
  • Bhasin M, et al., 2006, 13(1): 102-12.
  • Lachner M, et al., 2001, 410(6824): 116-20.
  • Rosenfeld JA, et al., 2009, BMC Genomics. 10: 143.
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    貨號: 100005-MM01-50
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