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HER3 / ErbB3 中和抗體

  • HER3 / ErbB3 Neutralizing Antibody
產品資料評論相關產品實驗方法
 ERBB3 抗體產品資訊
免疫原:Recombinant Human HER3 / ErbB3 protein (Catalog#10201-H08H)
Clone ID:mhA24
Ig類型:mouse (varialbe region) / human (kappa / IgG1
濃度:
內毒素:Please contact us for more information.
緩衝液:0.2 μm filtered solution in Histidine and Arginine buffer containing 120mM NaCl, 0.02% Tween 80, pH6.0
抗體製備方法:It is a chimeric monoclonal antibody combining the constant domains of the human IgG1 molecule with mouse variable regions. The variable region was obtained from a mouse immunized with purified, recombinant Human HER3 / ErbB3. The antibody was produced using recombinant antibody technology.
 ERBB3 Antibody Neutralization Application Image
HER3 / ErbB3 Neutralizing Antibody
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Caption:
Cell Proliferation Induced by NRG1-β1/HRG1-β1 was Neutralized by Human ErbB3/Her3 Antibody. Recombinant Human NRG1-1β1/HRG1-1β1 stimulates proliferation in the MCF-7 human breast cancer cell line. Proliferation elicited by Recombinant Human NRG1-1β1/HRG1-1β1 (40 ng/mL) is neutralized by increasing concentrations of Human ErbB3/Her3 Monoclonal Antibody (Catalog 10201-mhA24). The IC50 is typically 5.05-20.2 ng/mL.
Other ERBB3 Antibody Products
Immunochemical staining of human CD40 in human tonsil with rabbit polyclonal antibody (0.5 µg/mL, formalin-fixed paraffin embedded sections).
ERBB3/HER3 研究背景

ErbB3, also known as Her3(human epidermal growth factor receptor3), is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound glycoprotein has a neuregulin binding domain but has not an active kinase domain., and therefore can not mediate the intracellular signal transduction through protein phosphorylation. However, its heterodimer with ErbB2 or other EGFR members responsible for tyrosine phosphorylation forms a receptor complex with high affinity, and initiates the related pathway which lead to cell proliferation or differentiation. ErbB3 has been shown to implicated in numerous cancers, including prostate, bladder, and breast tumors. This protein has different isoforms derived from alternative splicing variants, and among which, the secreted isoform lacking the intermembrane region modulates the activity of membrane-bound form.

Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

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貨號: 10201-mhA24-500
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Datasheet & Documentation

All information of our products is subject to change without notice. Please refer to COA enclosed in shipped package for the newest information.
請注意:所有產品都是“僅用於科研,而不能用於診斷或治療用途”