Her2 / ERBB2 Matched ELISA Antibody Pair Set,Human

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Her2 / ERBB2 Matched ELISA Antibody Pair Set,Human General Information

Product name
Her2 / ERBB2 Matched ELISA Antibody Pair Set,Human
Assay type
Solid Phase Sandwich ELISA
Specificity
Quantitative determination of Human Her2 / ERBB2
Assay range
23.44-1500
Materials provided
1. Capture Antibody 1 mg/mL of rabbit anti-Human HER2 / ErbB2 / CD340 monoclonal antibody (in PBS, pH 7.4). Dilute to a working concentration of 1 μg/mL in PBS before coating. (Catalog: # 10004-R511)
2. Detection Antibody 0.1 mg/mL of rabbit anti-Human HER2 / ErbB2 / CD340 monoclonal antibody conjugated to horseradish-peroxidase (HRP) (in PBS, 50 % HRP-Protector, pH 7.4, store at 4℃). Dilute to working concentration of 0.5 μg/mL in detection antibody dilution buffer before use. (Catalog: # 10004-R205)
3. Standard Each vial contains 110 ng of recombinant Human HER2 / ErbB2 / CD340. Reconstitute with 1 mL detection antibody dilution buffer. After reconstitution, store at -20℃ to -80℃ in a manual defrost freezer. A seven-point standard curve using 2-fold serial dilutions in sample dilution buffer, and a high standard of 1500 pg/mL is recommended.
Product overview
This Her2 / ERBB2 Matched ELISA Antibody Pair Set,Human is a solid phase sandwich ELISA for quantitative determination of Human Her2 / ERBB2 . It contains Human Her2 / ERBB2 capture antibody, Human Her2 / ERBB2 detector antibody (HRP) and a highly purified HEK293-expressed recombinant Human Her2 / ERBB2 protein. This Pair Set is at affordable price for researchers.
Shipping
This Matched ELISA Antibody Pair Set is shipped at ambient temperature.
Storage
Capture Antibody: Aliquot and store at -20℃ to -80℃ for up to 6 months from date of receipt. Avoid repeated freeze-thaw cycles.
Detection Antibody: Store at 4℃ and protect it from prolonged exposure to light for up to 6 months from date of receipt. DO NOT FREEZE!
Standard: Store lyophilized standard at -20℃ to -80℃ for up to 6 months from date of receipt. Aliquot and store the reconstituted Standard at -80℃ for up to 1 month. Avoid repeated freeze-thaw cycles.

Her2 / ERBB2 Matched ELISA Antibody Pair Set,Human Images

Her2 / ERBB2 Matched ELISA Antibody Pair Set,Human: Alternative Names

CD340 Matched ELISA Antibody Pair Set, Human; ENV Matched ELISA Antibody Pair Set, Human; ENVW Matched ELISA Antibody Pair Set, Human; ERVWE1 Matched ELISA Antibody Pair Set, Human; HER-2 Matched ELISA Antibody Pair Set, Human; HER-2/neu Matched ELISA Antibody Pair Set, Human; HER2 Matched ELISA Antibody Pair Set, Human; HERV-7q Matched ELISA Antibody Pair Set, Human; HERV-W-ENV Matched ELISA Antibody Pair Set, Human; HERV7Q Matched ELISA Antibody Pair Set, Human; HERVW Matched ELISA Antibody Pair Set, Human; HERVWENV Matched ELISA Antibody Pair Set, Human; MLN 19 Matched ELISA Antibody Pair Set, Human; MLN19 Matched ELISA Antibody Pair Set, Human; NEU Matched ELISA Antibody Pair Set, Human; NGL Matched ELISA Antibody Pair Set, Human; TKR1 Matched ELISA Antibody Pair Set, Human

Her2 / ERBB2 Background Information

Epidermal growth factor receptor 2 (HER2), also known as ErbB2, NEU, and CD34, is a type I membrane glycoprotein, and belongs to the epidermal growth factor (EGF) receptor family. HER2 protein cannot bind growth factors due to the lacking of ligand binding domain of its own and autoinhibited constitutively. However, HER2 forms a heterodimer with other ligand-bound EGF receptor family members, therefore stabilizes ligand binding and enhances kinase-mediated activation of downstream molecules. HER2 plays a key role in development, cell proliferation and differentiation. HER2 gene has been reported to associate with malignancy and a poor prognosis in numerous carcinomas, including breast, prostate, ovarian, lung cancers and so on.Immune CheckpointImmunotherapyCancer ImmunotherapyTargeted Therapy
Full Name
erb-b2 receptor tyrosine kinase 2
References
  • Krawczyk N, et al. (2009) HER2 status on persistent disseminated tumor cells after adjuvant therapy may differ from initial HER2 status on primary tumor. Anticancer Res. 29(10): 4019-24.
  • Tumour exosomes inhibit binding of tumour-reactive antibodies to tumour cells and reduce ADCC
    Author
    Battke, C;Ruiss, R;Welsch, U;Wimberger, P;Lang, S;Jochum, S;Zeidler, R;
    Year
    2011
    Journal
    Cancer Immunol. Immunother.
    Application
    Antibodies and ELISA assays
  • Disposable Amperometric Immunosensor for the Determination of Human P53 Protein in Cell Lysates Using Magnetic Micro-Carriers
    Author
    Pedrero, M;Manuel de Villena, FJ;Muñoz-San Martín, C;Campuzano, S;Garranzo-Asensio, M;Barderas, R;Pingarrón, JM;
    Year
    2016
    Journal
    Biosensors (Basel)
    Application
    ELISA
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