All Galectin-1 reagents are produced in house and quality controlled, including 14 Galectin-1 Antibody, 2 Galectin-1 ELISA, 52 Galectin-1 Gene, 3 Galectin-1 IPKit, 3 Galectin-1 Protein, 3 Galectin-1 qPCR. All Galectin-1 reagents are ready to use.
Recombinant Galectin-1 proteins are expressed by E. coli with fusion tags as Native.
Galectin-1antibodies are validated with different applications, which are ELISA, WB, IP, ELISA(Cap), IHC-P, ELISA(Det).
Galectin-1cDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each Galectin-1 of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
Galectin-1ELISA Kit are quality controlled by 8 internation QC standard which guarantee every ELISA Kit with high quality.
Galectin-1 (Gal-1, GAL1), is a member of the galectins, a family of animal lectins ranging from Caenorhabditis elegans to humans, which is defined by their affinity for beta-galactosides and by significant sequence similarity in the carbohydrate-binding site. It is a homodimer with a subunit molecular mass of 14.5 kDa, which contains six cysteine residues per subunit. The cysteine residues should be in a free state in order to maintain a molecular structure that is capable of showing lectin activity. This endogenous lectin widely expressed at sites of inflammation and tumour growth, has been postulated as an attractive immunosuppressive agent to restore immune cell tolerance and homeostasis in autoimmune and inflammatory settings. On the other hand, galectin-1 contributes to different steps of tumour progression including cell adhesion, migration and tumour-immune escape, suggesting that blockade of galectin-1 might result in therapeutic benefits in cancer. Several potential glycoprotein ligands for galectin-1 have been identified, including lysosome-associated membrane glycoproteins and fibronectin, laminin, as well as T-cell glycoproteins CD43 and CD45. Evidence points to Gal-1 and its ligands as one of the master regulators of such immune responses as T-cell homeostasis and survival, T-cell immune disorders, inflammation and allergies as well as host-pathogen interactions.