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Galectin-1/LGALS1  Protein, Antibody, ELISA Kit, cDNA Clone

描述: Active  
表達宿主: E. coli  
10290-HNAE-500
10290-HNAE-50
10290-HNAE-100
10290-HNAE-10
10290-HNAE-1
500 µg 
50 µg 
100 µg 
10 µg 
1 mg 
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  • Slide 1
描述: Active  
表達宿主: E. coli  
50100-MNAE-500
50100-MNAE-5
50100-MNAE-20
50100-MNAE-100
50100-MNAE-1
500 µg 
5 µg 
20 µg 
100 µg 
1 mg 
Add to Cart
  • Slide 1
表達宿主: E. coli  
80248-RNAE-50
80248-RNAE-100
50 µg 
100 µg 
Add to Cart
  • Slide 1

Galectin-1/LGALS1 相关研究领域

Galectin-1/LGALS1 相關信號通路

    Galectin-1/LGALS1 概述&蛋白信息

    Galectin-1/LGALS1 研究背景

    基因概述: OMIM - description for Galectin-1 :
    General information above from NCBI
    亞單位結構: Homodimer. Binds LGALS3BP. Interacts with CD2, CD3, CD4, CD7, CD43 and CD45. Interacts with laminin (via poly-N-acetyllactosamine). Interacts with SUSD2. {ECO:0000269|PubMed:11146440, ECO:0000269|PubMed:1386213, ECO:0000269|PubMed:15476813, ECO:0000269|PubMed:18796645, ECO:0000269|PubMed:23131994}.
    亞細胞定位: Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:14617626}.
    組織特異性: Expressed in placenta, maternal decidua and fetal membranes. Within placenta, expressed in trophoblasts, stromal cells, villous endothelium, syncytiotrophoblast apical membrane and villous stroma. Within fetal membranes, expressed in amnion, chorioamniotic mesenchyma and chorion (at protein level). Expressed in cardiac, smooth, and skeletal muscle, neurons, thymus, kidney and hematopoietic cells. {ECO:0000269|PubMed:18824694, ECO:0000269|PubMed:19497882}.
    相似的序列: Contains 1 galectin domain. {ECO:0000255|PROSITE-ProRule:PRU00639}.
    General information above from UniProt

    Galectin-1 (Gal-1, GAL1), is a member of the galectins, a family of animal lectins ranging from Caenorhabditis elegans to humans, which is defined by their affinity for beta-galactosides and by significant sequence similarity in the carbohydrate-binding site. It is a homodimer with a subunit molecular mass of 14.5 kDa, which contains six cysteine residues per subunit. The cysteine residues should be in a free state in order to maintain a molecular structure that is capable of showing lectin activity. This endogenous lectin widely expressed at sites of inflammation and tumour growth, has been postulated as an attractive immunosuppressive agent to restore immune cell tolerance and homeostasis in autoimmune and inflammatory settings. On the other hand, galectin-1 contributes to different steps of tumour progression including cell adhesion, migration and tumour-immune escape, suggesting that blockade of galectin-1 might result in therapeutic benefits in cancer. Several potential glycoprotein ligands for galectin-1 have been identified, including lysosome-associated membrane glycoproteins and fibronectin, laminin, as well as T-cell glycoproteins CD43 and CD45. Evidence points to Gal-1 and its ligands as one of the master regulators of such immune responses as T-cell homeostasis and survival, T-cell immune disorders, inflammation and allergies as well as host-pathogen interactions.

    Galectin-1/LGALS1 別稱

    Galectin-1/LGALS1 相關文獻

  • Gaudet AD, et al. (2005) Expression and functions of galectin-1 in sensory and motoneurons. Curr Drug Targets. 6(4): 419-25.
  • Kadoya T, et al. (2006) Structural and functional studies of galectin-1: a novel axonal regeneration-promoting activity for oxidized galectin-1. Curr Drug Targets. 6(4): 375-83.
  • Camby I, et al. (2006) Galectin-1: a small protein with major functions. Glycobiology. 16(11): 137R-157R.
  • Salatino M, et al. (2008) Galectin-1 as a potential therapeutic target in autoimmune disorders and cancer. Expert Opin Biol Ther. 8(1): 45-57.
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