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HIV  Gag-p24

HIV  Gag-p24 蛋白和抗體

GAG-P24 蛋白GAG-P24 抗體GAG-P24 基因GAG-P24 

HIV Gag-p24 背景

Human Immunodeficiency Virus (HIV) can be divided into two major types, HIV type 1 (HIV-1) and HIV type 2 (HIV-2). HIV-1 is related to viruses found in chimpanzees and gorillas living in western Africa. HIV-2 is related to viruses found in sooty mangabeys. HIV-1 viruses may be further divided into groups. The HIV-1 group M viruses predominate and are responsible for the AIDS pandemic. Some of the HIV-1 group M subtypes are known to be more virulent or are resistant to different medications. HIV-2 viruses are thought to be less virulent and transmissible than HIV-1 M group viruses. Gag protein from HIV-1 is a polyprotein, which, during viral maturation, is cleaved to release matrix p17, core p24 and nucleocapsid proteins. Capsid protein p24 forms the conical core that encapsulates the genomic RNA-nucleocapsid complex in the virion. Most core are conical, with only 7% tubular. The core is constituted by capsid protein hexamer subunits. The core is dissassembled soon after virion entry. The p24 antigen contains epitopes that prime helper CD4 T-cells, which have been demonstrated to be protective and it can elicit lymphocyte proliferation. p24 is likely to be an integral part of any multicomponent HIV vaccine.

HIV Gag-p24 參考文獻

  1. Yang X., J. et al., 2005, Virol. 79: 12132-47.
  2. Beddows, S. et al., 2007, Virology. 360 (2): 329-40.
  3. Mendu, DR. et al., 2007, Biochem Biophys Res Commun. 363 (3): 466-71.
  4. Du, SX. et al., 2009, Virology. 395 (1): 33-44.
  5. Donayre-Torres, A.J. et al., 2009, Virol J  6 :17
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