GCSF Receptor / G-CSFR: GCSF Receptor / G-CSFR Protein | GCSF Receptor / G-CSFR Antibody

GCSF Receptor / G-CSFR Gene family

GCSF Receptor / G-CSFR Background

Granulocyte Colony Stimulating Factor Receptor (G-CSFR), also known as CD114, which belongs to the cytokine receptor superfamily, is a cell surface receptor for colony stimulating factor 3 (CSF3). It is a critical regulator of granulopoiesis. This type I membrane protein has a composite structure consisting of an immunoglobulin(Ig)-like domain, a cytokine receptor-homologous (CRH) domain and three fibronectin type III (FNIII) domains in the extracellular region. Mutations in the G-CSF receptor leading to carboxy-terminal truncation transduce hyperproliferative growth responses, and are implicated in the pathological progression of severe congenital neutropenia (SCN) to acute myelogenous leukemia (AML). Additionally, autocrine/paracrine stimulation of G-CSFR may be important in the biology of solid tumors, including metastasis.

Reference for GCSF Receptor / G-CSFR

  • Kasper B, et al. (1999) Association of src-kinase Lyn and non-src-kinase Syk with the granulocyte colony-stimulating factor receptor (G-CSFR) is not abrogated in neutrophils from severe congenital neutropenia patients with point mutations in the G-CSFR mRNA. Int J Hematol. 70(4): 241-7.
  • Hollenstein U, et al. (2000) Endotoxin down-modulates granulocyte colony-stimulating factor receptor (CD114) on human neutrophils. J Infect Dis. 182(1): 343-6.
  • Kindwall-Keller TL, et al. (2008) Role of the proteasome in modulating native G-CSFR expression. Cytokine. 43(2): 114-23.
  • Beel K, et al. (2009) G-CSF receptor (CSF3R) mutations in X-linked neutropenia evolving to acute myeloid leukemia or myelodysplasia. Haematologica. 94(10): 1449-52.

GCSF Receptor / G-CSFR Protein

GCSF Receptor / G-CSFR protein function

Receptor for granulocyte colony-stimulating factor (CSF3), essential for granulocytic maturation. Plays a crucial role in the proliferation, differientation and survival of cells along the neutrophilic lineage. In addition it may function in some adhesion or recognition events at the cell surface. {ECO:0000269|PubMed:7514305}.

GCSF Receptor / G-CSFR protein expression

Tissue specificity

One or several isoforms have been found in myelogenous leukemia cell line KG-1, leukemia U-937 cell line, in bone marrow cells, placenta, and peripheral blood granulocytes. Isoform GCSFR-2 is found only in leukemia U-937 cells. Isoform GCSFR-3 is highly expressed in placenta.

GCSF Receptor / G-CSFR protein sequence

This sequence information is just for reference only.From Uniport

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GCSF Receptor / G-CSFR Antibody

There are 5 GCSF Receptor / G-CSFR antibodies which are validated in multiple tissues with various applications, including ELISA, ELISA(Det), ICC/IF, IF, ELISA(Cap), FCM. There are 1 GCSF Receptor / G-CSFR antibody for ELISA, 1 GCSF Receptor / G-CSFR antibody for ELISA(Det), 2 GCSF Receptor / G-CSFR antibody for ICC/IF, 2 GCSF Receptor / G-CSFR antibody for IF, 1 GCSF Receptor / G-CSFR antibody for ELISA(Cap), 2 GCSF Receptor / G-CSFR antibody for FCM. Among all these GCSF Receptor / G-CSFR antibodies, there are 5 anti-GCSF Receptor / G-CSFR mouse monoclonal antibodies . All the GCSF Receptor / G-CSFR anbodies are produced in house and all are in stock. GCSF Receptor / G-CSFR antibody customerized service is available.

GCSF Receptor / G-CSFR Gene

CSF3R gene / cDNA is a protein-coding gene which located on 1p34.3. The CSF3R gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog.201 organisms have orthologs with human gene CSF3R.