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Frizzled-4/FZD4/CD344  Protein, Antibody, ELISA Kit, cDNA Clone

表達宿主: Human Cells  
16137-H08H-50
16137-H08H-200
50 µg 
200 µg 
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  • Slide 1
表達宿主: Human Cells  
16137-H02H-50
16137-H02H-100
50 µg 
100 µg 
Add to Cart
  • Slide 1
表達宿主: Human Cells  
80377-R08H-50
80377-R08H-10
50 µg 
10 µg 
Add to Cart
  • Slide 1
表達宿主: Human Cells  
80377-R02H-50
80377-R02H-100
50 µg 
100 µg 
Add to Cart
  • Slide 1

Frizzled-4/FZD4/CD344 相关研究领域

Frizzled-4/FZD4/CD344 相關蛋白、抗體、cDNA基因、ELISA試劑盒

Frizzled-4/FZD4/CD344 概述&蛋白信息

Frizzled-4/FZD4/CD344 研究背景

亞單位結構: Interacts with MAGI3 and norrin (NDP). Component of a complex, at least composed of TSPAN12, FZD4 and norrin (NDP) (By similarity). {ECO:0000250}.
結構域: Lys-Thr-X-X-X-Trp motif interacts with the PDZ doman of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway. {ECO:0000250}.; The FZ domain is involved in binding with Wnt ligands. {ECO:0000250}.
亞細胞定位: Membrane; Multi-pass membrane protein. Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
組織特異性: Almost ubiquitous. Largely expressed in adult heart, skeletal muscle, ovary, and fetal kidney. Moderate amounts in adult liver, kidney, pancreas, spleen, and fetal lung, and small amounts in placenta, adult lung, prostate, testis, colon, fetal brain and liver.
翻譯後修飾: Ubiquitinated by ZNRF3, leading to its degradation by the proteasome. {ECO:0000269|PubMed:22575959}.
相關疾病 : DISEASE: Vitreoretinopathy, exudative 1 (EVR1) [MIM:133780]: A disorder of the retinal vasculature characterized by an abrupt cessation of growth of peripheral capillaries, leading to an avascular peripheral retina. This may lead to compensatory retinal neovascularization, which is thought to be induced by hypoxia from the initial avascular insult. New vessels are prone to leakage and rupture causing exudates and bleeding, followed by scarring, retinal detachment and blindness. Clinical features can be highly variable, even within the same family. Patients with mild forms of the disease are asymptomatic, and their only disease related abnormality is an arc of avascular retina in the extreme temporal periphery. In many ways the disease resembles retinopathy of prematurity but there is no evidence of prematurity or small birth weight in the patient history. {ECO:0000269|PubMed:12172548, ECO:0000269|PubMed:14507768, ECO:0000269|PubMed:15035989, ECO:0000269|PubMed:15223780, ECO:0000269|PubMed:15370539, ECO:0000269|PubMed:15488808, ECO:0000269|PubMed:15733276, ECO:0000269|PubMed:15981244, ECO:0000269|PubMed:17093393, ECO:0000269|PubMed:19172507, ECO:0000269|PubMed:19324841, ECO:0000269|PubMed:20340138}. Note=The disease is caused by mutations affecting the gene represented in this entry.
相似的序列: Belongs to the G-protein coupled receptor Fz/Smo family. {ECO:0000305}.; Contains 1 FZ (frizzled) domain. {ECO:0000255|PROSITE-ProRule:PRU00090}.
General information above from UniProt

Frizzled-4/FZD4/CD344 別稱

Frizzled-4/FZD4/CD344 相關文獻

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