|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.
The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.
|雪貂 CD20/MS4A1 基因全長cDNA ORF克隆 (表達載體), C-GFPSpark 標籤||FG60004-ACG|
|雪貂 CD20/MS4A1 基因全長cDNA ORF克隆 (表達載體), C-OFPSpark 標籤||FG60004-ACR|
|雪貂 CD20/MS4A1 基因全長cDNA ORF克隆 (表達載體), C-Flag 標籤||FG60004-CF|
|雪貂 CD20/MS4A1 基因全長cDNA ORF克隆 (表達載體), C-His 標籤||FG60004-CH|
|雪貂 CD20/MS4A1 基因全長cDNA ORF克隆 (表達載體), C-Myc 標籤||FG60004-CM|
|雪貂 CD20/MS4A1 基因全長cDNA ORF克隆 (表達載體), C-HA 標籤||FG60004-CY|
|雪貂 CD20/MS4A1 基因全長cDNA ORF(克隆載體)||FG60004-G|
|雪貂 CD20/MS4A1 基因全長cDNA ORF克隆 (表達載體), N-Flag 標籤||FG60004-NF|
|雪貂 CD20/MS4A1 基因全長cDNA ORF克隆 (表達載體), N-His 標籤||FG60004-NH|
|雪貂 CD20/MS4A1 基因全長cDNA ORF克隆 (表達載體), N-Myc 標籤||FG60004-NM|
|雪貂 CD20/MS4A1 基因全長cDNA ORF克隆 (表達載體), N-HA 標籤||FG60004-NY|
|雪貂 CD20/MS4A1 基因全長cDNA ORF克隆 (表達載體)||FG60004-UT|
CD20 (membrane-spanning 4-domains, subfamily A, member 1), also known as MS4A1, is a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. CD20 / MS4A1 is expressed on all stages of B cell development except the first and last. CD20 / MS4A1 is present from pre-pre B cells through memory cells, but not on either pro-B cells or plasma cells. It is a B-lymphocyte surface molecule which plays a role in the development and differentiation of B-cells into plasma cells. CD20 / MS4A1may be involved in the regulation of B-cell activation and proliferation. Defects in CD20 / MS4A1 are the cause of immunodeficiency common variable type 5(CVID5). CVID5 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low.