Text Size:AAA
留言    收藏

雪貂 CD20 / MS4A1 抗體, 兔單抗

    產品資料評論相關產品實驗方法
    雪貂 MS4A1 抗體產品資訊
    免疫原:Recombinant Ferret CD20 / MS4A1 protein (Catalog#60004-F08H)
    Clone ID:071
    Ig類型:Rabbit IgG
    濃度:
    內毒素:
    緩衝液:0.2 μm filtered solution in PBS
    抗體製備方法:This antibody was obtained from a rabbit immunized with purified, recombinant Ferret CD20 / MS4A1 (rF CD20 / MS4A1; Catalog#60004-F08H; Glu213-Pro297).
    Other MS4A1 Antibody Products
    Immunochemical staining of human CCNF in human brain with rabbit polyclonal antibody (1 µg/mL, formalin-fixed paraffin embedded sections).
    CD20/MS4A1  研究背景

    CD20 (membrane-spanning 4-domains, subfamily A, member 1), also known as MS4A1, is a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. CD20 / MS4A1 is expressed on all stages of B cell development except the first and last. CD20 / MS4A1 is present from pre-pre B cells through memory cells, but not on either pro-B cells or plasma cells. It is a B-lymphocyte surface molecule which plays a role in the development and differentiation of B-cells into plasma cells. CD20 / MS4A1may be involved in the regulation of B-cell activation and proliferation. Defects in CD20 / MS4A1 are the cause of immunodeficiency common variable type 5(CVID5). CVID5 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low.

    Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

    雪貂 CD20/MS4A1  參考資料
  • Tedder TF, et al. (1988) Isolation and structure of a cDNA encoding the B1 (CD20) cell-surface antigen of human B lymphocytes. Proc Natl Acad Sci. 85(1): 208-12.
  • Cragg MS, et al. (2005) The biology of CD20 and its potential as a target for mAb therapy. Curr Dir Autoimmun. 8: 140-74..
  • Polyak MJ, et al. (2003) A cholesterol-dependent CD20 epitope detected by the FMC7 antibody. Leukemia. 17(7): 1384-9.
  • Product nameProduct name
    Size / Price
    貨號: 60004-R071-100
    目錄價: 
    單價:      (You Save: )

    Datasheet & Documentation

    All information of our products is subject to change without notice. Please refer to COA enclosed in shipped package for the newest information.
    請注意:所有產品都是“僅用於科研,而不能用於診斷或治療用途”