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FYN  Protein, Antibody, ELISA Kit, cDNA Clone

FYN 相关研究领域

FYN 相關信號通路

FYN 概述&蛋白信息

FYN 研究背景

催化活性: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. {ECO:0000255|PROSITE-ProRule:PRU10028}.
輔因數: Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
酶調控: ENZYME REGULATION: Inhibited by phosphorylation of Tyr-531 by leukocyte common antigen and activated by dephosphorylation of this site.
亞單位結構: Interacts (via its SH3 domain) with PIK3R1 and PRMT8. Interacts with FYB, PAG1, and SH2D1A. Interacts with CD79A (tyrosine-phosphorylated form); the interaction increases FYN activity. Interacts (via SH2 domain) with CSF1R (tyrosine phosphorylated) (By similarity). Interacts with TOM1L1 (phosphorylated form). Interacts with KDR (tyrosine phosphorylated). Interacts (via SH3 domain) with KLHL2 (via N-terminus) (By similarity). Interacts with SH2D1A and SLAMF1. Interacts (via its SH3 domain) with HEV ORF3 protein. Interacts with ITCH; the interaction phosphorylates ITCH and negatively regulates its activity. Interacts with FASLG. Interacts with RUNX3. Interacts with KIT. Interacts with EPHA8; possible downstream effector of EPHA8 in regulation of cell adhesion. Interacts with PTK2/FAK1; this interaction leads to PTK2/FAK1 phosphorylation and activation. Interacts with CAV1; this interaction couples integrins to the Ras-ERK pathway. Interacts with UNC119. {ECO:0000250, ECO:0000269|PubMed:10498895, ECO:0000269|PubMed:10790433, ECO:0000269|PubMed:11518702, ECO:0000269|PubMed:12545174, ECO:0000269|PubMed:14757743, ECO:0000269|PubMed:16387660, ECO:0000269|PubMed:17925405, ECO:0000269|PubMed:19807924, ECO:0000269|PubMed:20100835, ECO:0000269|PubMed:8394019, ECO:0000269|PubMed:8681387, ECO:0000269|PubMed:9038210, ECO:0000269|PubMed:9207119, ECO:0000269|PubMed:9741627}.
亞細胞定位: Cytoplasm. Nucleus. Cell membrane. Note=Present and active in lipid rafts. Palmitoylation is crucial for proper trafficking.
組織特異性: Isoform 1 is highly expressed in the brain. Isoform 2 is expressed in cells of hemopoietic lineages, especially T-lymphocytes. {ECO:0000269|PubMed:10196263}.
翻譯後修飾: Autophosphorylated at Tyr-420. Phosphorylation on the C-terminal tail at Tyr-531 by CSK maintains the enzyme in an inactive state (By similarity). PTPRC/CD45 dephosphorylates Tyr-531 leading to activation. Ultraviolet B (UVB) strongly increase phosphorylation at Thr-12 and kinase activity, and promotes translocation from the cytoplasm to the nucleus. Dephosphorylation at Tyr-420 by PTPN2 negatively regulates T-cell receptor signaling. {ECO:0000250, ECO:0000269|PubMed:10196263, ECO:0000269|PubMed:15537652, ECO:0000269|PubMed:1699196, ECO:0000269|PubMed:22080863}.; Palmitoylation at Cys-3 and Cys-6 regulates subcellular location. {ECO:0000250}.
相似的序列: Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily. {ECO:0000255|PROSITE-ProRule:PRU00159}.; Contains 1 protein kinase domain. {ECO:0000255|PROSITE-ProRule:PRU00159}.; Contains 1 SH2 domain. {ECO:0000255|PROSITE-ProRule:PRU00191}.; Contains 1 SH3 domain. {ECO:0000255|PROSITE-ProRule:PRU00192}.
General information above from UniProt

FYN 別稱

SLK,SYN,p59-FYN, [homo-sapiens]
AI448320,AW552119, [mus-musculus]

FYN 相關文獻

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