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FGF21  基因

All FGF21 Reagents

HP100794 
MP200433 

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FGF21 相关研究领域

FGF21 相關信號通路

    FGF21 相關蛋白、抗體、cDNA基因、ELISA試劑盒

    FGF21 概述&蛋白信息

    FGF21 研究背景

    基因概述: The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. The function of this growth factor has not yet been determined.
    General information above from NCBI
    亞單位結構: Interacts (via C-terminus) with KLB; this interaction is direct. Interacts with FGFR4. {ECO:0000269|PubMed:15902306, ECO:0000269|PubMed:18829467, ECO:0000269|PubMed:19117008}.
    亞細胞定位: Secreted {ECO:0000305}.
    相似的序列: Belongs to the heparin-binding growth factors family. {ECO:0000305}.
    General information above from UniProt

    Fibroblast growth factor 21 (FGF21) is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. FGF-21 has a hydrophobic amino terminus, which is a typical signal sequence, and appears to be a secreted protein. The metabolic regulator fibroblast growth factor 21 (FGF21) has antidiabetic properties in animal models of diabetes and obesity. FGF21 is a novel adipokine associated with obesity-related metabolic complications in humans. The paradoxical increase of serum FGF21 in obese individuals, which may be explained by a compensatory response or resistance to FGF21, warrants further investigation. FGF-21, which we have identified as a novel metabolic factor, exhibits the therapeutic characteristics necessary for an effective treatment of diabetes.

    FGF21 別稱

    FGF21,Fibroblast Growth Factor 21, [Cynomolgus]
    FGF21,FGF-21,UNQ3115/PRO10196, [human]
    Fgf21,FGF-21, [mouse]

    FGF21 相關文獻

  • Zhang X, et al. (2008) Serum FGF21 levels are increased in obesity and are independently associated with the metabolic syndrome in humans. Diabetes. 57(5): 1246-53.
  • Lundåsen T, et al. (2007) PPARalpha is a key regulator of hepatic FGF21. Biochem Biophys Res Commun. 360(2): 437-40.
  • Kharitonenkov A, et al. (2005) FGF-21 as a novel metabolic regulator. J Clin Invest. 115(6): 1627-35.
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