FABP6: FABP6 Protein | FABP6 Antibody

FABP6 Gene family

FABP6 Background

Gastrotropin, also known as Fatty acid-binding protein 6, Ileal lipid-binding protein, ILBP, Intestinal 15 kDa protein, Intestinal bile acid-binding protein, I-BABP and FABP6, is a cytoplasm protein which belongs to the calycin superfamily and Fatty-acid binding protein (FABP) family. Isoform 2 of FABP6 is expressed in colorectal adenocarcinomas and their adjacent normal mucosa (at protein level). Isoform 1 of FABP6 is expressed in the jejunum, ileum, cecum and ascending colon intestine. Isoform 2 is expressed in the gallbladder, duodenum, jejunum, ileum, cecum, ascending, transverse and descending colon, sigmoid colon and rectum. FABP6 / I-BABP is a cancer-related protein that acts as an intracellular transporter of bile acid in the ileal epithelium. FABP6 / I-BABP may also play an important role in early carcinogenesis.

Reference for FABP6

  • Kurz M., et al., 2003, Proteins 50:312-328.
  • Ohmachi,T. et al., 2006, Clin Cancer Res.12(17):5090-5.
  • Fang C., et al., 2007, Cancer Res. 67:9039-9046.
  • Szczerbal,I. et al., 2007, Cytogenet Genome Res.118(1):63-6.

FABP6 Protein

FABP6 protein function

Binds to bile acids and is involved in enterohepatic bile acid metabolism. Required for efficient apical to basolateral transport of conjugated bile acids in ileal enterocytes (By similarity). In vitro binds to bile acids in the order: deoxycholic acid > cholic acid > chenodeoxycholic acid and respective BA conjugation modifies affinities in the order taurine-conjugated > glycine-conjugated > unconjugated bile acids. Stimulates gastric acid and pepsinogen secretion (By similarity). {ECO:0000250|UniProtKB:P10289, ECO:0000250|UniProtKB:P51162, ECO:0000269|PubMed:12486725, ECO:0000269|PubMed:7588781}.; Isoform 2: Essential for the survival of colon cancer cells to bile acid-induced apoptosis. {ECO:0000269|PubMed:17909007}.

FABP6 protein expression

Tissue specificity

Isoform 1 is expressed in the jejunum, ileum, cecum and ascending colon intestine. Isoform 2 is xpressed in the gallbladder, duodenum, jejunum, ileum, cecum, ascending, transverse and descending colon, sigmoid colon and rectum. Isoform 2 is expressed in colorectal adenocarcinomas and their adjacent normal mucosa (at protein level).

Induction

Isoform 1 is up-regulated by chenodeoxycholic acid (CDCA) via the FXR transcription pathway. Isoform 2 is up-regulated by NF-kappa-B and in all stages of colorectal adenocarcinoma. Isoform 1 is not up-regulated in all stages of colorectal adenocarcinoma.

FABP6 protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    128.00
  • Mass (Da)
    14.00

FABP6 Antibody

There are 5 FABP6 antibodies which are validated in multiple tissues with various applications, including IHC-P, ELISA, FCM, ICC/IF. There are 1 FABP6 antibody for IHC-P, 3 FABP6 antibody for ELISA, 1 FABP6 antibody for FCM, 1 FABP6 antibody for ICC/IF. Among all these FABP6 antibodies, there are 3 anti-FABP6 rabbit polyclonal antibodies , 2 anti-FABP6 rabbit monoclonal antibodies . All the FABP6 anbodies are produced in house and all are in stock. FABP6 antibody customerized service is available.

FABP6 Gene

FABP6 gene / cDNA is a protein-coding gene which located on 5q33.3. The FABP6 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog.220 organisms have orthologs with human gene FABP6.