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FABP2 / I-FABP  Protein, Antibody, ELISA Kit, cDNA Clone

表達宿主: E. coli  
10130-H08E-200
10130-H08E-100
200 µg 
100 µg 
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FABP2 / I-FABP 相关研究领域

FABP2 / I-FABP 相關信號通路

    FABP2 / I-FABP 概述&蛋白信息

    FABP2 / I-FABP 研究背景

    基因概述: The intracellular fatty acid-binding proteins (FABPs) belong to a multigene family with nearly twenty identified members. FABPs are divided into at least three distinct types, namely the hepatic-, intestinal- and cardiac-type. They form 14-15 kDa proteins and are thought to participate in the uptake, intracellular metabolism and/or transport of long-chain fatty acids. They may also be responsible in the modulation of cell growth and proliferation. Intestinal fatty acid-binding protein 2 gene contains four exons and is an abundant cytosolic protein in small intestine epithelial cells. This FABP2 gene has a polymorphism at codon 54 that identified an alanine-encoding allele and a threonine-encoding allele. Thr-54 protein is associated with increased fat oxidation and insulin resistance. [provided by RefSeq, Jul 2008]
    General information above from NCBI
    結構域: Forms a beta-barrel structure that accommodates the hydrophobic ligand in its interior.
    亞細胞定位: Cytoplasm.
    組織特異性: Expressed in the small intestine and at much lower levels in the large intestine. Highest expression levels in the jejunum. {ECO:0000269|PubMed:14563446}.
    誘導: By EGF. {ECO:0000269|PubMed:10070036}.
    相似的序列: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. {ECO:0000305}.
    General information above from UniProt

    Fatty acid binding protein (FABP) is one of the intracellular proteins, with a low molecular weight of approximately 15 kDa, that plays important roles in the transportation and metabolism of long-chain fatty acids. FABP family proteins could be used as tissue specific injury marker based on the following characteristics of FABP. The intestinal fatty acid binding protein (I-FABP), or fatty acid-binding protein 2 (FABP2), an intracellular protein expressed only in the intestine, involved in the absorption and intracellular transport of dietary long chain fatty acids. The FABP2 gene is proposed as a candidate gene for diabetes because the protein it codes is involved in fatty acid (FA) absorption and metabolism. Numerous studies have assessed FABP2 gene variants. A transition of G to A at codon 54 of FABP2 results in an amino acid substitution (Ala54 to Thr54), which is common in diverse populations and results in increased FA absorption in vivo. Some evidence indicates that this variant may be associated with type 2 diabetes. This polymorphism was associated with some cardiovascular risk factors. The cytosolic human intestinal fatty acid binding protein (hFABP2) is proposed to be involved in intestinal absorption of long-chain fatty acids. FABP2 may also help maintain energy homeostasis by functioning as a lipid sensor.

    FABP2 / I-FABP 別稱

    FABP2,FABPI,I-FABP,MGC133132, [human]
    Fabp2,Fabpi,I-FABP, [mouse]

    FABP2 / I-FABP 相關文獻

  • de Luis DA, et al. (2007) Influence of ALA54THR polymorphism of fatty acid-binding protein 2 on obesity and cardiovascular risk factors. Horm Metab Res. 39(11): 830-4.
  • Klapper M, et al.. (2007) The human intestinal fatty acid binding protein (hFABP2) gene is regulated by HNF-4alpha. Biochem Biophys Res Commun. 356(1): 147-52.
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