All ErbB4 reagents are produced in house and quality controlled, including 5 ErbB4 Antibody, 27 ErbB4 Gene, 7 ErbB4 Lysate, 7 ErbB4 Protein, 2 ErbB4 qPCR. All ErbB4 reagents are ready to use.
Recombinant ErbB4 proteins are expressed by HEK293 Cells, Baculovirus-Insect cells with fusion tags as C-His, C-human IgG1-Fc, C-human IgG1-Fc & His.
ErbB4antibodies are validated with different applications, which are ELISA, IHC-P.
ErbB4cDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each ErbB4 of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
ERBB4 is a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. ERBB4 is expressed at highest levels in brain, heart, kidney, in addition to skeletal muscle, parathyroid, cerebellum, pituitary, spleen, testis and breast. And lower levels in thymus, lung, salivary gland, and pancreas. It specifically binds to and is activated by neuregulins, NRG-2, NRG-3, heparin-binding EGF-like growth factor, betacellulin and NTAK. ERBB4 also can be activated by other factors and induces a variety of cellular responses including mitogenesis and differentiation. ERBB4 regulates development of the heart, the central nervous system and the mammary gland, gene transcription, cell proliferation, differentiation, migration and apoptosis. It is required for normal cardiac muscle differentiation during embryonic development, and for postnatal cardiomyocyte proliferation. ERBB4 also play a role on the normal development of the embryonic central nervous system, especially for normal neural crest cell migration and normal axon guidance. It is required for mammary gland differentiation, induction of milk proteins and lactation.