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EFNB2/Ephrin-B2  Protein, Antibody, ELISA Kit, cDNA Clone

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EFNB2/Ephrin-B2 相关研究领域

EFNB2/Ephrin-B2 相關信號通路

    EFNB2/Ephrin-B2 相關蛋白、抗體、cDNA基因、ELISA試劑盒

    EFNB2/Ephrin-B2 相關蛋白、抗體、cDNA基因、ELISA試劑盒

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    EFNB2/Ephrin-B2 概述&蛋白信息

    EFNB2/Ephrin-B2 相關資訊

    EFNB2/Ephrin-B2 研究背景

    基因概述: This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNB class ephrin which binds to the EPHB4 and EPHA3 receptors.
    General information above from NCBI
    亞單位結構: Interacts with PDZRN3 (By similarity). Binds to the receptor tyrosine kinases EPHA4, EPHB4 and EPHA3. Binds to Hendra virus and Nipah virus G protein. {ECO:0000250, ECO:0000269|PubMed:16007075, ECO:0000269|PubMed:16477309, ECO:0000269|PubMed:16867992, ECO:0000269|PubMed:19836338, ECO:0000269|PubMed:19875447}.
    亞細胞定位: Membrane; Single-pass type I membrane protein.
    組織特異性: Lung and kidney.
    翻譯後修飾: Inducible phosphorylation of tyrosine residues in the cytoplasmic domain. {ECO:0000250}.
    相似的序列: Belongs to the ephrin family. {ECO:0000255|PROSITE-ProRule:PRU00884}.; Contains 1 ephrin RBD (ephrin receptor-binding) domain. {ECO:0000255|PROSITE-ProRule:PRU00884}.
    General information above from UniProt

    EphrinB2 also known as EFNB2 is a member of the ephrin family. EphrinB2 is involved in establishing arterial versus venous identity and perhaps in anastamosing arterial and venous vessels at their junctions. The transmembrane-associated ephrin ligands and their Eph family of receptor tyrosine kinases are expressed by cells of the SVZ. Eph/ephrin interactions are implicated in axon guidance, neural crest cell migration, establishment of segmental boundaries, and formation of angiogenic capillary plexi. Eph receptors and ephrins are divided into two subclasses, A and B, based on binding specificities. Ephrin subclasses are further distinguished by their mode of attachment to the plasma membrane: ephrin-A ligands bind EphA receptors and are anchored to the plasma membrane via a glycosylphosphatidylinositol (GPI) linkage, whereas ephrin-B ligands bind EphB receptors and are anchored via a transmembrane domain. An exception is the EphA4 receptor, which binds both subclasses of ephrins. EphrinB2 expression progressively extends from the arterial endothelium to surrounding smooth muscle cells and to pericytes, suggesting that ephrin-B2 may play an important role during formation of the arterial muscle wall.

    EFNB2/Ephrin-B2 別稱

    EFNB2/Ephrin-B2 相關文獻

  • Wang HU, et al. (1998) Molecular distinction and angiogenic interaction between embryonic arteries and veins revealed by ephrin-B2 and its receptor Eph-B4. Cell. 93(5): 741-53.
  • Gale NW, et al. (2001) Ephrin-B2 selectively marks arterial vessels and neovascularization sites in the adult, with expression in both endothelial and smooth-muscle cells. Dev Biol. 230(2): 151-60.
  • Shin D, et al. (2001) Expression of ephrinB2 identifies a stable genetic difference between arterial and venous vascular smooth muscle as well as endothelial cells, and marks subsets of microvessels at sites of adult neovascularization. Dev Biol. 230(2): 139-50.
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