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EphB4/Eph Receptor B4  Protein, Antibody, ELISA Kit, cDNA Clone

表達宿主: Baculovirus-Insect Cells  
10235-H20B1-50
10235-H20B1-20
50 µg 
20 µg 
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表達宿主: Human Cells  
10235-H08H-200
10235-H08H-100
200 µg 
100 µg 
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表達宿主: Human Cells  
10235-H02H-200
10235-H02H-100
200 µg 
100 µg 
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表達宿主: Human Cells  
10235-HCCH-200
10235-HCCH-100
200 µg 
100 µg 
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表達宿主: Human Cells  
50582-M08H-200
50582-M08H-100
200 µg 
100 µg 
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表達宿主: Human Cells  
50582-M02H-200
50582-M02H-100
200 µg 
100 µg 
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EphB4/Eph Receptor B4 相关研究领域

EphB4/Eph Receptor B4 相關信號通路

EphB4/Eph Receptor B4 相關蛋白、抗體、cDNA基因、ELISA試劑盒

EphB4/Eph Receptor B4 概述&蛋白信息

EphB4/Eph Receptor B4 研究背景

基因概述: Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene binds to ephrin-B2 and plays an essential role in vascular development.
General information above from NCBI
催化活性: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. {ECO:0000255|PROSITE-ProRule:PRU10028}.
亞單位結構: Heterotetramer upon binding of the ligand. The heterotetramer is composed of an ephrin dimer and a receptor dimer. Oligomerization is probably required to induce biological responses (By similarity). {ECO:0000250}.
亞細胞定位: Cell membrane {ECO:0000269|PubMed:8188704}; Single-pass type I membrane protein {ECO:0000269|PubMed:8188704}.
組織特異性: Abundantly expressed in placenta but also detected in kidney, liver, lung, pancreas, skeletal muscle and heart. Expressed in primitive and myeloid, but not lymphoid, hematopoietic cells. Also observed in cell lines derived from liver, breast, colon, lung, melanocyte and cervix. {ECO:0000269|PubMed:8188704}.
發育階段: Expressed in fetal heart, lung, liver and to a lower extent in brain. Not expressed in adult brain. {ECO:0000269|PubMed:8188704}.
翻譯後修飾: Phosphorylated; autophosphorylation is stimulated by EFNB2.
相似的序列: Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily. {ECO:0000255|PROSITE-ProRule:PRU00159}.; Contains 1 Eph LBD (Eph ligand-binding) domain. {ECO:0000255|PROSITE-ProRule:PRU00883}.; Contains 2 fibronectin type-III domains. {ECO:0000255|PROSITE-ProRule:PRU00316}.; Contains 1 protein kinase domain. {ECO:0000255|PROSITE-ProRule:PRU00159}.; Contains 1 SAM (sterile alpha motif) domain. {ECO:0000255|PROSITE-ProRule:PRU00184}.
General information above from UniProt

Ephrin type-B receptor 4 is a protein that in humans is encoded by the EPHB4 gene. It is a single-pass type I membrane protein belonging to the ephrin receptor subfamily of protein kinase superfamily. Members of the ephrin and Eph family are local mediators of cell function through largely contact-dependent processes in development and in maturity. Furthermore, EphB4 protein and the corresponding ligand Ephrin-B2 contribute to tumor growth in various human tumors. EphB4 protein has tumor suppressor activities and that regulation of cell proliferation, extracellular matrix remodeling, and invasive potential are important mechanisms of tumor suppression. Therefore, Ephrin-B2/EphB4 may be recognized as a novel prognostic indicator for cancers.

EphB4/Eph Receptor B4 別稱

HTK,MYK1,TYRO11, [homo-sapiens]
EphB4,HTK,MYK1,TYRO11, [human]
AI042935,Ephb4,Htk,MDK2,Myk1,Tyro11, [mouse]
Htk,MDK2,Myk1,Tyro11,AI042935, [mus-musculus]

EphB4/Eph Receptor B4 相關文獻

  • Davalos V, et al. (2006) EPHB4 and survival of colorectal cancer patients. Cancer Res. 66(18): 8943-8.
  • Zhao C, et al. (2006) Bidirectional ephrinB2-EphB4 signaling controls bone homeostasis. Cell Metab. 4(2): 111-21.
  • Kertesz N, et al. (2006) The soluble extracellular domain of EphB4 (sEphB4) antagonizes EphB4-EphrinB2 interaction, modulates angiogenesis, and inhibits tumor growth. Blood. 107(6): 2330-8.
  • Noren NK, et al. (2007) Paradoxes of the EphB4 receptor in cancer. Cancer Res. 67(9): 3994-7.
  • Taylor AC, et al. (2007) EphB4 expression along adult rat microvascular networks: EphB4 is more than a venous specific marker. Microcirculation. 14(3): 253-67.
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