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EphB3/HEK2/Eph Receptor B3  Protein, Antibody, ELISA Kit, cDNA Clone

表達宿主: Baculovirus-Insect Cells  
13925-H20B1-50
13925-H20B1-20
50 µg 
20 µg 
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描述: Active  
表達宿主: Human Cells  
50581-M08H-200
50581-M08H-100
200 µg 
100 µg 
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表達宿主: Human Cells  
81593-R08H-50
81593-R08H-200
50 µg 
200 µg 
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EphB3/HEK2/Eph Receptor B3 相关研究领域

EphB3/HEK2/Eph Receptor B3 相關信號通路


EphB3/HEK2/Eph Receptor B3 相關蛋白、抗體、cDNA基因、ELISA試劑盒

EphB3/HEK2/Eph Receptor B3 相關蛋白、抗體、cDNA基因、ELISA試劑盒

EphB3/HEK2/Eph Receptor B3 概述&蛋白信息

EphB3/HEK2/Eph Receptor B3 研究背景

基因概述: OMIM - description for EphB3 :
General information above from NCBI
催化活性: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. {ECO:0000255|PROSITE-ProRule:PRU10028}.
亞單位結構: Heterotetramer upon binding of the ligand. The heterotetramer is composed of an ephrin dimer and a receptor dimer. Oligomerization is probably required to induce biological responses (By similarity). {ECO:0000250}.
亞細胞定位: Cell membrane {ECO:0000269|PubMed:15536074}; Single-pass type I membrane protein {ECO:0000269|PubMed:15536074}. Cell projection, dendrite {ECO:0000250}.
組織特異性: Ubiquitous.
翻譯後修飾: Phosphorylated. Autophosphorylates upon ligand-binding. Autophosphorylation on Tyr-614 is required for interaction with SH2 domain-containing proteins. {ECO:0000269|PubMed:9674711}.
相似的序列: Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily. {ECO:0000255|PROSITE-ProRule:PRU00159}.; Contains 1 Eph LBD (Eph ligand-binding) domain. {ECO:0000255|PROSITE-ProRule:PRU00883}.; Contains 2 fibronectin type-III domains. {ECO:0000255|PROSITE-ProRule:PRU00316}.; Contains 1 protein kinase domain. {ECO:0000255|PROSITE-ProRule:PRU00159}.; Contains 1 SAM (sterile alpha motif) domain. {ECO:0000255|PROSITE-ProRule:PRU00184}.
General information above from UniProt

Ephrin type-B receptor 3, also known as EphB3 or HEK2, belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family which 16 known receptors (14 found in mammals) are involved: EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHA9, EPHA10, EPHB1, EPHB2, EPHB3, EPHB4, EPHB5, EPHB6. The Eph family of receptor tyrosine kinases (comprising EphA and EphB receptors) has been implicated in synapse formation and the regulation of synaptic function and plasticity6. Ephrin receptors are components of cell signalling pathways involved in animal growth and development, forming the largest sub-family of receptor tyrosine kinases (RTKs). Ligand-mediated activation of Ephs induce various important downstream effects and Eph receptors have been studied for their potential roles in the development of cancer. EphB receptor tyrosine kinases are enriched at synapses, suggesting that these receptors play a role in synapse formation or function. We find that EphrinB binding to EphB induces a direct interaction of EphB with NMDA-type glutamate receptors. This interaction occurs at the cell surface and is mediated by the extracellular regions of the two receptors, but does not require the kinase activity of EphB.

EphB3/HEK2/Eph Receptor B3 別稱

ETK2,HEK2,TYRO6, [homo-sapiens]
HEK2,TYRO6,EphB3,ETK2, [human]
AW456895,Cek10,Etk2,HEK2,MDK5,Ephb3,Sek4,Tyro6, [mouse]
Etk2,HEK2,MDK5,Sek4,Cek10,Tyro6,AW456895, [mus-musculus]

EphB3/HEK2/Eph Receptor B3 相關文獻

  • Bergemann AD, et al. (1998) Ephrin-B3, a ligand for the receptor EphB3, expressed at the midline of the developing neural tube. Oncogene. 16(4): 471-80.
  • Hock B, et al. (1998) PDZ-domain-mediated interaction of the Eph-related receptor tyrosine kinase EphB3 and the ras-binding protein AF6 depends on the kinase activity of the receptor. Proc Natl Acad Sci U S A. 95(17): 9779-84.
  • Liu X, et al. (2006) EphB3: an endogenous mediator of adult axonal plasticity and regrowth after CNS injury. J Neurosci. 26(12): 3087-101.
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