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EphB2/Eph Receptor B2  Protein, Antibody, ELISA Kit, cDNA Clone

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10762-H03H-50
10762-H03H-100
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表達宿主: Human Cells  
10762-HCCH-50
10762-HCCH-100
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100 µg 
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表達宿主: Baculovirus-Insect Cells  
10762-H20B1-50
10762-H20B1-20
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20 µg 
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描述: Active  
表達宿主: Human Cells  
10762-H08H-50
10762-H08H-100
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表達宿主: Human Cells  
51367-M08H-500
51367-M08H-200
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表達宿主: Human Cells  
51367-M02H-200
51367-M02H-100
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表達宿主: E. coli  
70039-DNAE-50
70039-DNAE-100
70039-DNAE-10
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10 µg 
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EphB2/Eph Receptor B2 相关研究领域

EphB2/Eph Receptor B2 相關信號通路

EphB2/Eph Receptor B2 相關蛋白、抗體、cDNA基因、ELISA試劑盒

EphB2/Eph Receptor B2 概述&蛋白信息

EphB2/Eph Receptor B2 研究背景

基因概述: OMIM - description for EphB2 :
General information above from NCBI
催化活性: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. {ECO:0000255|PROSITE-ProRule:PRU10028}.
亞單位結構: Heterotetramer upon binding of the ligand. The heterotetramer is composed of an ephrin dimer and a receptor dimer. Oligomerization is probably required to induce biological responses (By similarity). Interacts (via PDZ-binding motif) with GRIP1 and PICK1 (via PDZ domain) (By similarity). Interacts with ARHGEF15; mediates ARHGEF15 phosphorylation, ubiquitination and degradation by the proteasome. Interacts with AQP1; involved in endolymph production in the inner ear. {ECO:0000250, ECO:0000269|PubMed:17897949}.
亞細胞定位: Cell membrane; Single-pass type I membrane protein. Cell projection, axon {ECO:0000250}. Cell projection, dendrite {ECO:0000250}.
組織特異性: Brain, heart, lung, kidney, placenta, pancreas, liver and skeletal muscle. Preferentially expressed in fetal brain.
相關疾病 : DISEASE: Prostate cancer (PC) [MIM:176807]: A malignancy originating in tissues of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet-ring cell carcinoma and neuroendocrine carcinoma. {ECO:0000269|PubMed:15300251, ECO:0000269|PubMed:16155194}. Note=The gene represented in this entry may be involved in disease pathogenesis. EPHB2 mutations have been found in a prostate cancer cell line derived from a brain metastasis.
相似的序列: Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily. {ECO:0000255|PROSITE-ProRule:PRU00159}.; Contains 1 Eph LBD (Eph ligand-binding) domain. {ECO:0000255|PROSITE-ProRule:PRU00883}.; Contains 2 fibronectin type-III domains. {ECO:0000255|PROSITE-ProRule:PRU00316}.; Contains 1 protein kinase domain. {ECO:0000255|PROSITE-ProRule:PRU00159}.; Contains 1 SAM (sterile alpha motif) domain. {ECO:0000255|PROSITE-ProRule:PRU00184}.
General information above from UniProt

Ephrin type-B receptor 2, also known as EphB2, belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family which 16 known receptors (14 found in mammals) are involved: EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHA9, EPHA10, EPHB1, EPHB2, EPHB3, EPHB4, EPHB5, EPHB6. EphB2 receptor tyrosine kinase phosphorylates syndecan-2 and that this phosphorylation event is crucial for syndecan-2 clustering and spine formation. The Eph family of receptor tyrosine kinases (comprising EphA and EphB receptors) has been implicated in synapse formation and the regulation of synaptic function and plasticity6. Ephrin receptors are components of cell signalling pathways involved in animal growth and development, forming the largest sub-family of receptor tyrosine kinases (RTKs). Ligand-mediated activation of Ephs induce various important downstream effects and Eph receptors have been studied for their potential roles in the development of cancer. EphB receptor tyrosine kinases are enriched at synapses, suggesting that these receptors play a role in synapse formation or function. We find that EphrinB binding to EphB induces a direct interaction of EphB with NMDA-type glutamate receptors. This interaction occurs at the cell surface and is mediated by the extracellular regions of the two receptors, but does not require the kinase activity of EphB.

EphB2/Eph Receptor B2 別稱

DRT,EK5,ERK,CAPB,Hek5,PCBC,EPHT3,Tyro5, [homo-sapiens]
ERK,CAPB,DRT,EphB2,EPHT3,Hek5,MGC87492,PCBC,Tyro5, [human]
ERK,Cek5,Drt,Ephb2,ETECK,Hek5,Nuk,Prkm5,Qek5,RP23-426N4.7,Sek3,Tyro5, [mouse]
Drt,Erk,Nuk,Cek5,Hek5,Qek5,Sek3,ETECK,Prkm5,Tyro5, [mus-musculus]

EphB2/Eph Receptor B2 相關文獻

  • Zisch AH, et al. (1998) Complex formation between EphB2 and Src requires phosphorylation of tyrosine 611 in the EphB2 juxtamembrane region. Oncogene. 16 (20): 2657-70.
  • Yu HH, et al. (2001) Multiple signaling interactions of Abl and Arg kinases with the EphB2 receptor. Oncogene. 20 (30): 3995-4006.
  • Zisch AH, et al. (2000) Replacing two conserved tyrosines of the EphB2 receptor with glutamic acid prevents binding of SH2 domains without abrogating kinase activity and biological responses. Oncogene. 19 (2): 177-87.
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