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EphA7/Eph Receptor A7  Protein, Antibody, ELISA Kit, cDNA Clone

表達宿主: Baculovirus-Insect Cells  
11657-H20B1-50
11657-H20B1-20
50 µg 
20 µg 
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表達宿主: Human Cells  
11657-H08H-50
11657-H08H-100
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100 µg 
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表達宿主: Human Cells  
50587-M08H-200
50587-M08H-100
200 µg 
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表達宿主: Human Cells  
80109-R02H-50
80109-R02H-200
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200 µg 
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表達宿主: Human Cells  
80109-R08H-500
80109-R08H-200
500 µg 
200 µg 
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EphA7/Eph Receptor A7 相关研究领域

EphA7/Eph Receptor A7 相關信號通路

EphA7/Eph Receptor A7 相關蛋白、抗體、cDNA基因、ELISA試劑盒

EphA7/Eph Receptor A7 相關蛋白、抗體、cDNA基因、ELISA試劑盒

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EphA7/Eph Receptor A7 概述&蛋白信息

EphA7/Eph Receptor A7 相關資訊

EphA7/Eph Receptor A7 研究背景

基因概述: OMIM - description for EphA7 :
General information above from NCBI
催化活性: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. {ECO:0000255|PROSITE-ProRule:PRU10028}.
亞單位結構: Heterotetramer upon binding of the ligand. The heterotetramer is composed of an ephrin dimer and a receptor dimer. Oligomerization is probably required to induce biological responses (By similarity). Interacts (via PDZ-binding motif) with GRIP1 and PICK1 (via PDZ domain) (By similarity). {ECO:0000250}.
亞細胞定位: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
組織特異性: Widely expressed.
翻譯後修飾: Phosphorylated. {ECO:0000250}.
相似的序列: Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily. {ECO:0000255|PROSITE-ProRule:PRU00159}.; Contains 1 Eph LBD (Eph ligand-binding) domain. {ECO:0000255|PROSITE-ProRule:PRU00883}.; Contains 2 fibronectin type-III domains. {ECO:0000255|PROSITE-ProRule:PRU00316}.; Contains 1 protein kinase domain. {ECO:0000255|PROSITE-ProRule:PRU00159}.; Contains 1 SAM (sterile alpha motif) domain. {ECO:0000255|PROSITE-ProRule:PRU00184}.
General information above from UniProt

Ephrin type-A receptor 7, also known as EphA7, belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family which 16 known receptors (14 found in mammals) are involved: EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHA9, EPHA10, EPHB1, EPHB2, EPHB3, EPHB4, EPHB5, EPHB6. The Eph family of receptor tyrosine kinases (comprising EphA and EphB receptors) has been implicated in synapse formation and the regulation of synaptic function and plasticity6. Eph receptor-mediated signaling, which is triggered by ephrins7, probably modifies the properties of synapses during synaptic activation and remodeling. Ephrin receptors are components of cell signalling pathways involved in animal growth and development, forming the largest sub-family of receptor tyrosine kinases (RTKs). Ligand-mediated activation of Ephs induce various important downstream effects and Eph receptors have been studied for their potential roles in the development of cancer. Down-regulation of EphA7 secondary to hypermethylation has been reported in colorectal cancer. The expression of EphA7 was reduced in all tested gastric cancer cell lines; however, there is marked variability in expression among gastric carcinoma specimens. EphA7 may have roles in the pathogenesis and development of gastric carcinomas.

EphA7/Eph Receptor A7 別稱

EHK3,EHK-3,EK11,EPHA7,HEK11, [human]
Cek11,Ebk,Ehk3,EHK-3,Hek11,Mdk1,RP23-33D17.1,Epha7, [mouse]
Ehk-3,Ehk3, [Rat]

EphA7/Eph Receptor A7 相關文獻

  • Rashid T, et al. (2005) Opposing gradients of ephrin-As and EphA7 in the superior colliculus are essential for topographic mapping in the mammalian visual system. Neuron. 47(1): 57-69.
  • Wang J, et al. (2007) Differential expression of EphA7 receptor tyrosine kinase in gastric carcinoma. Hum Pathol. 38(11): 1649-56.
  • Rogers JH, et al. (1999) Distribution of the receptor EphA7 and its ligands in development of the mouse nervous system. Brain Res Mol Brain Res. 74(1-2): 225-30.
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