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EphA6 / EHK2 / Eph Receptor A6  Protein, Antibody, ELISA Kit, cDNA Clone

描述: Active  
表達宿主: Human Cells  
50630-M08H-200
50630-M08H-100
200 µg 
100 µg 
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描述: Active  
表達宿主: Human Cells  
50630-M02H-200
50630-M02H-100
200 µg 
100 µg 
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EphA6 / EHK2 / Eph Receptor A6 相关研究领域

EphA6 / EHK2 / Eph Receptor A6 相關信號通路

EphA6 / EHK2 / Eph Receptor A6 相關蛋白、抗體、cDNA基因、ELISA試劑盒

EphA6 / EHK2 / Eph Receptor A6 概述&蛋白信息

EphA6 / EHK2 / Eph Receptor A6 研究背景

基因概述: OMIM - description for EphB3 :
General information above from NCBI
催化活性: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. {ECO:0000255|PROSITE-ProRule:PRU10028}.
亞單位結構: Heterotetramer upon binding of the ligand. The heterotetramer is composed of an ephrin dimer and a receptor dimer. Oligomerization is probably required to induce biological responses (By similarity). {ECO:0000250}.
亞細胞定位: Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
組織特異性: Expressed in brain and testis. {ECO:0000269|PubMed:14726470}.
相似的序列: Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily. {ECO:0000255|PROSITE-ProRule:PRU00159}.; Contains 1 Eph LBD (Eph ligand-binding) domain. {ECO:0000255|PROSITE-ProRule:PRU00883}.; Contains 2 fibronectin type-III domains. {ECO:0000255|PROSITE-ProRule:PRU00316}.; Contains 1 protein kinase domain. {ECO:0000255|PROSITE-ProRule:PRU00159}.; Contains 1 SAM (sterile alpha motif) domain. {ECO:0000255|PROSITE-ProRule:PRU00184}.
General information above from UniProt

Ephrin type-A receptor 6, also known as EphA6 or EHK2, belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family which 16 known receptors (14 found in mammals) are involved: EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHA9, EPHA10, EPHB1, EPHB2, EPHB3, EPHB4, EPHB5, EPHB6. The Eph family of receptor tyrosine kinases (comprising EphA and EphB receptors) has been implicated in synapse formation and the regulation of synaptic function and plasticity6. Eph receptor−mediated signaling, which is triggered by ephrins7, probably modifies the properties of synapses during synaptic activation and remodeling. Ephrin receptors are components of cell signalling pathways involved in animal growth and development, forming the largest sub-family of receptor tyrosine kinases (RTKs). Ligand-mediated activation of Ephs induce various important downstream effects and Eph receptors have been studied for their potential roles in the development of cancer. In the vomeronasal system, Ephrin-A5/EphA6 interactions mediate attraction or adhesion rather than repulsion.

EphA6 / EHK2 / Eph Receptor A6 別稱

EHK2,EK12,EPA6,EHK-2,HEK12,PRO57066, [homo-sapiens]
EPA6,EphA6,PRO57066,UNQ6114,DKFZp434C1418,EHK-2,FLJ35246, [human]
Epha6,Hek12,m-ehk2,Ehk2, [mouse]
Ehk2,Hek12,m-ehk2, [mus-musculus]

EphA6 / EHK2 / Eph Receptor A6 相關文獻

  • Wilkinson DG. (2000) Eph receptors and ephrins: regulators of guidance and assembly. Int Rev Cytol. 196: 177-244.
  • Yamaguchi Y, et al. (2004) Eph receptors in the adult brain. Curr Opin Neurobiol. 14 (3): 288-96.
  • Hafner C, et al. (2004) Differential gene expression of Eph receptors and ephrins in benign human tissues and cancers. Clin Chem. 50 (3): 490-9.
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