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Enterovirus  VP0

Enterovirus  VP0 蛋白和抗體

VP0 蛋白VP0 抗體VP0 基因VP0 
Product NameMoleculeCat No.Package/Price 
人腸道病毒71型 VP0 蛋白 (His & GST 標籤)VP040013-V20B-10
40013-V20B-20
10 µg/
20 µg/
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Enterovirus VP0 背景

Human enterovirus 71 genome polyprotein is a member of the picornaviruses polyprotein family. It contains two peptidase C3 domains, one RdRp catalytic domain, one SF3 helicase domain. Genome polyprotein is cleaved into the following 12 chains: Protein VP0 (VP4-VP2), Protein VP4 (P1A), Protein VP2 (P1B), Protein VP3 (P1C), Protein VP1 (P1D), Picornain 2A (P2A), Protein 2B (P2B), Protein 2C (P2C), Protein 3A (P3A), Protein 3B (P3B), Picornain 3C (Protease 3C) and RNA-directed RNA polymerase 3D-POL (P3D-POL). VP0 precursor is a component of immature procapsids. Capsid proteins VP1, VP2, VP3 and VP4 form a closed capsid enclosing the viral positive strand RNA genome. VP4 lies on the inner surface of the protein shell formed by VP1, VP2 and VP3. All the three latter proteins contain a beta-sheet structure called beta-barrel jelly roll. Together they form an icosahedral capsid composed of 60 copies of each VP1, VP2, and VP3, with a diameter of approximately 300 Angstroms. VP1 is situated at the 12 fivefold axes, whereas VP2 and VP3 are located at the quasi-sixfold axes.

Enterovirus VP0 參考文獻

  1. Brown B.A., et al., 1995, Virus Res. 39:195-206.
  2. Tang W.-F. et al., 2007, J. Biol. Chem. 282:5888-5898.
  3. Huang,S.C. et al., 2008, Virus Res. 131 (2):250-9.
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