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Ebola virus  Matrix protein VP24 / Ebola virus VP24

Ebola virus  Matrix protein VP24 / Ebola virus VP24 蛋白和抗體

EBOV-VP24 蛋白EBOV-VP24 抗體EBOV-VP24 基因EBOV-VP24 
Product NameMoleculeCat No.Package/Price 
埃博拉病毒 EBOV (subtype Zaire, strain H.sapiens-wt/GIN/2014/Kissidougou-C15) VP24 蛋白 (His 標籤)Matrix protein VP24 / Ebola virus VP2440454-V07E-20
40454-V07E-100
20 µg/
100 µg/
Add to Cart
Add to Cart
埃博拉病毒 EBOV (subtype Bundibugyo, strain Uganda 2007) VP24 蛋白 (His 標籤)Matrix protein VP24 / Ebola virus VP2440456-V07E-20
40456-V07E-100
20 µg/
100 µg/
Add to Cart
Add to Cart

Ebola virus Matrix protein VP24 / Ebola virus VP24 背景

VP24 is a minor matrix protein of Ebola virus, which plays an important role in nucleocapsid assembly, virus release and replication. It is resistant to trypsin digestion in the absence of Triton X-100. When expressed in mammalian cells, it prefers to oligomerize into tetramers. The oligomerization ability is believed to be critical for the role of VP24 in nucleocapsid assembly; it is considered that the N-terminal region of VP24, especially the amino acids 90 to 130, is responsible for oligomer formation. VP24 is identified present in virus-like particles produced by VP24-expressing mammalian cells. Recent studies demonstrate that VP24 also acts as a suppressor of immune system during the early stages of host defense. VP24 can bind to karyopherins such as karyopherin α1, which transports the transcription factor STAT1 to the nucleus, inhibiting signaling downstream of interferon (IFN). Moreover, VP24 can block the p38-α stimulated by IFNβ, preventing the signal transduction in MKK3/6-p38 mitogen-activated protein (MAP) kinase pathway. In addition, direct binding between VP24 and STAT1 is discovered, which may result in STAT1 degradation or the failure of STAT1 phosphorylation, and thus suppress the host immune response. There will be attempts to design novel anti-Ebola virus therapeutics by impairing the multiple functions of VP24.

Ebola virus Matrix protein VP24 / Ebola virus VP24 參考文獻

  1. Mateo M, et al. Knockdown of Ebola virus VP24 impairs viral nucleocapsid assembly and prevents virus replication. J Infect Dis. 2011 Nov;204 Suppl 3:S892-6. doi: 10.1093/infdis/jir311.
  2. Han Z, et al. Biochemical and functional characterization of the Ebola virus VP24 protein: implications for a role in virus assembly and budding. J Virol. 2003 Feb;77(3):1793-800.
  3. Zhang AP, et al. The ebolavirus VP24 interferon antagonist: know your enemy. Virulence. 2012 Aug 15;3(5):440-5. doi: 10.4161/viru.21302.
  4. Zhang AP, et al. The ebola virus interferon antagonist VP24 directly binds STAT1 and has a novel, pyramidal fold. PLoS Pathog. 2012 Feb;8(2):e1002550. doi: 10.1371/journal.ppat.1002550.
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