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Ebola virus  Glycoprotein / Ebola virus GP

Ebola virus  Glycoprotein / Ebola virus GP 蛋白和抗體

EBOV-G 蛋白EBOV-G 抗體EBOV-G 基因EBOV-G 
Product NameMoleculeCat No.Package/Price 
埃博拉病毒 EBOV (subtype Sudan, strain Gulu) GP-RBD / Glycoprotein 蛋白 (Fc 標籤)Glycoprotein / Ebola virus GP40094-V02H1-100
40094-V02H1-20
100 µg/
20 µg/
Add to Cart
Add to Cart
埃博拉病毒 EBOV (Subtype Sudan, strain Gulu) Glycoprotein / GP1 (mucin domain deleted) 蛋白 (aa:Met1-Asp320, His 標籤)Glycoprotein / Ebola virus GP40094-V08B-100
40094-V08B-20
100 µg/
20 µg/
Add to Cart
Add to Cart
埃博拉病毒 EBOV (Subtype Sudan, strain Gulu) Glycoprotein / GP 蛋白 (aa:Met1-Asn637, His 標籤)Glycoprotein / Ebola virus GP40094-V08B1-20
40094-V08B1-100
20 µg/
100 µg/
Add to Cart
Add to Cart
埃博拉病毒 EBOV (subtype Sudan, strain Gulu) GP1 / Glycoprotein 蛋白 (His 標籤)Glycoprotein / Ebola virus GP40094-V08B2-100
40094-V08B2-20
100 µg/
20 µg/
Add to Cart
Add to Cart
埃博拉病毒 EBOV (Subtype Sudan, strain Gulu) Glycoprotein / GP1 (mucin domain deleted) 蛋白 (aa:Met1-Asp320, His 標籤)Glycoprotein / Ebola virus GP40094-V08H-100
40094-V08H-20
100 µg/
20 µg/
Add to Cart
Add to Cart
埃博拉病毒 EBOV (subtype Sudan, strain Gulu) GP / Glycoprotein 蛋白 (His 標籤)Glycoprotein / Ebola virus GP40094-V08H1-100
40094-V08H1-20
100 µg/
20 µg/
Add to Cart
Add to Cart
埃博拉病毒 EBOV (subtype Sudan, strain Gulu) GP1 / Glycoprotein 蛋白 (His 標籤)Glycoprotein / Ebola virus GP40094-V08H2-100
40094-V08H2-20
100 µg/
20 µg/
Add to Cart
Add to Cart
埃博拉病毒 EBOV (subtype Zaire, strain Mayinga 1976) Glycoprotein / GP-RBD (Receptor Binding Domain) 蛋白 (Fc 標籤)Glycoprotein / Ebola virus GP40304-V02H1-20
40304-V02H1-100
20 µg/
100 µg/
Add to Cart
Add to Cart
埃博拉病毒 EBOV (subtype Zaire, strain Mayinga 1976) Glycoprotein / GP 蛋白 (His 標籤)Glycoprotein / Ebola virus GP40304-V08B1-20
40304-V08B1-100
20 µg/
100 µg/
Add to Cart
Add to Cart
埃博拉病毒 EBOV (subtype Zaire, strain Mayinga 1976) GP-RBD / Glycoprotein 蛋白 (His 標籤)Glycoprotein / Ebola virus GP40304-V08H-100
40304-V08H-20
100 µg/
20 µg/
Add to Cart
Add to Cart
埃博拉病毒 EBOV (subtype Zaire, strain Mayinga 1976) GP-RBD / Glycoprotein 蛋白Glycoprotein / Ebola virus GP40304-VCCH1-100
40304-VCCH1-20
100 µg/
20 µg/
Add to Cart
Add to Cart
埃博拉病毒 EBOV (subtype Bundibugyo, strain Uganda 2007) Glycoprotein / GP-RBD (Receptor Binding Domain) 蛋白 (Fc 標籤)Glycoprotein / Ebola virus GP40368-V02H-20
40368-V02H-100
20 µg/
100 µg/
Add to Cart
Add to Cart
埃博拉病毒 EBOV (subtype Bundibugyo, strain Uganda 2007) GP-RBD / Glycoprotein 蛋白 (Fc 標籤)Glycoprotein / Ebola virus GP40368-V02H1-100
40368-V02H1-20
100 µg/
20 µg/
Add to Cart
Add to Cart
埃博拉病毒 EBOV (subtype Bundibugyo, strain Uganda 2007) GP1 / Glycoprotein 蛋白 (His 標籤)Glycoprotein / Ebola virus GP40368-V08B-100
40368-V08B-20
100 µg/
20 µg/
Add to Cart
Add to Cart
埃博拉病毒 EBOV (subtype Zaire, strain H.sapiens-wt/GIN/2014/Kissidougou-C15) Glycoprotein / GP-RBD 蛋白 (Fc 標籤)Glycoprotein / Ebola virus GP40442-V02H-20
40442-V02H-100
20 µg/
100 µg/
Add to Cart
Add to Cart
埃博拉病毒 EBOV (subtype Zaire, strain H.sapiens-wt/GIN/2014/Kissidougou-C15) GP2 / Glycoprotein 蛋白 (Fc 標籤)Glycoprotein / Ebola virus GP40442-V04H-100
40442-V04H-20
100 µg/
20 µg/
Add to Cart
Add to Cart
埃博拉病毒 EBOV (subtype Zaire, strain H.sapiens-wt/GIN/2014/Kissidougou-C15) Glycoprotein / GP1 蛋白 (His 標籤)Glycoprotein / Ebola virus GP40442-V08B-20
40442-V08B-100
20 µg/
100 µg/
Add to Cart
Add to Cart
埃博拉病毒 EBOV (subtype Zaire, strain H.sapiens-wt/GIN/2014/Kissidougou-C15) Glycoprotein / GP 蛋白 (His 標籤)Glycoprotein / Ebola virus GP40442-V08B1-20
40442-V08B1-100
20 µg/
100 µg/
Add to Cart
Add to Cart
埃博拉病毒 EBOV (subtype Zaire, strain H.sapiens-wt/GIN/2014/Kissidougou-C15) Glycoprotein / GP-RBD 蛋白 (His 標籤)Glycoprotein / Ebola virus GP40442-V08H-20
40442-V08H-100
20 µg/
100 µg/
Add to Cart
Add to Cart
埃博拉病毒 EBOV (subtype Zaire, strain H.sapiens-wt/GIN/2014/Kissidougou-C15) GP1 / Glycoprotein 蛋白 (His 標籤)Glycoprotein / Ebola virus GP40442-V08H1-100
40442-V08H1-20
100 µg/
20 µg/
Add to Cart
Add to Cart
埃博拉病毒 EBOV (subtype Zaire, strain H.sapiens-wt/GIN/2014/Kissidougou-C15) GP / Glycoprotein 蛋白 (His 標籤)Glycoprotein / Ebola virus GP40442-V08H2-100
40442-V08H2-20
100 µg/
20 µg/
Add to Cart
Add to Cart
埃博拉病毒 EBOV (subtype Zaire, strain H.sapiens-wt/GIN/2014/Kissidougou-C15) Glycoprotein / GP (Virion spike glycoprotein) 蛋白 (His 標籤)Glycoprotein / Ebola virus GP40442-V08H4-100
40442-V08H4-20
100 µg/
20 µg/
Add to Cart
Add to Cart

Ebola virus Glycoprotein / Ebola virus GP 背景

The fourth gene of the EBOV genome encodes a 160-kDa envelope-attached glycoprotein (GP) and a 110 kDa secreted glycoprotein (sGP). Both GP and sGP have an identical 295-residue N-terminus, however, they have different C-terminal sequences. Recently, great attention has been paid to GP for vaccines design and entry inhibitors isolation. GP is a class I fusion protein which assembles as trimers on viral surface and plays an important role in virus entry and attachment. Mature GP is a disulfide-linked heterodimer formed by two subunits, GP1 and GP2, which are generated from the proteolytical process of GP precursor (pre-GP) by cellular furin during virus assembly . The GP1 subunit contains a mucin domain and a receptor-binding domain (RBD); the GP2 subunit has a fusion peptide, a helical heptad-repeat (HR) region, a transmembrane (TM) domain, and a 4-residue cytoplasmic tail. The RBD of GP1 mediates the interaction of EBOV with cellular receptor (e.g. DC-SIGN/LSIGN, TIM-1, hMGL, NPC1, β-integrins, folate receptor-α, and Tyro3 family receptors), of which TIM1 and NPC1 are essential for EBOV entry; the mucin domain having N- and O-linked glycans enhances the viral attachment to cellular hMGL, and participates in shielding key neutralization epitopes, which helps the virus evades immune elimination. There are large conformation changes of GP2 during membrane fusion, which enhance the insertion of fusion loop into cellular membrane and facilitate the release of viral nucleocapsid core to cytoplasm.

Ebola virus Glycoprotein / Ebola virus GP 參考文獻

  1. Volchkov VE, et al. Processing of the Ebola virus glycoprotein by the proprotein convertase furin. Proc Natl Acad Sci U S A. 1998 May 12;95(10):5762-7.
  2. Lee JE, et al. Structure of the Ebola virus glycoprotein bound to an antibody from a human survivor. Nature. 2008 Jul 10;454(7201):177-82. doi: 10.1038/nature07082.
  3. Hood CL, et al. Biochemical and structural characterization of cathepsin L-processed Ebola virus glycoprotein: implications for viral entry and immunogenicity. J Virol. 2010 Mar;84(6):2972-82. doi: 10.1128/JVI.02151-09.
  4. Cook JD and Lee JE. The secret life of viral entry glycoproteins: moonlighting in immune evasion. PLoS Pathog. 2013 May;9(5):e1003258. doi: 10.1371/journal.ppat.1003258.
  5. Miller EH and Chandran K. Filovirus entry into cells - new insights. Curr Opin Virol. 2012 Apr;2(2):206-14. doi: 10.1016/j.coviro.2012.02.015.
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