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IRE1/ERN1  Protein, Antibody, ELISA Kit, cDNA Clone

表達宿主: Baculovirus-Insect Cells  
11905-H20B-50
11905-H20B-20
50 µg 
20 µg 
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  • Slide 1
表達宿主: Baculovirus-Insect Cells  
11905-HNCB-50
11905-HNCB-20
50 µg 
20 µg 
Add to Cart
  • Slide 1

IRE1/ERN1 相关研究领域

IRE1/ERN1 相關信號通路

    IRE1/ERN1 概述&蛋白信息

    IRE1/ERN1 研究背景

    基因概述: The protein encoded by this ERN1 gene is the ER to nucleus signalling 1 protein, a human homologue of the yeast Ire1 gene product. ERN1 protein possesses intrinsic kinase activity and an endoribonuclease activity and it is important in altering gene expression as a response to endoplasmic reticulum-based stress signals. [provided by RefSeq, Jul 2008]
    General information above from NCBI
    催化活性: ATP + a protein = ADP + a phosphoprotein. {ECO:0000269|PubMed:9637683}.
    輔因數: Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    酶調控: ENZYME REGULATION: The kinase domain is activated by trans-autophosphorylation. Kinase activity is required for activation of the endoribonuclease domain. {ECO:0000269|PubMed:12637535, ECO:0000269|PubMed:9637683}.
    亞單位結構: Interacts with DAB2IP (via PH domain); the interaction occurs in a ER stress-induced dependent manner and is required for subsequent recruitment of TRAF2 to ERN1 (By similarity). Homodimer; disulfide-linked. Dimer formation is driven by hydrophobic interactions within the N-terminal luminal domains and stabilized by disulfide bridges. Also binds HSPA5, a negative regulator of the unfolded protein response. This interaction may disrupt homodimerization and prevent activation of ERN1. Interacts with TAOK3 and TRAF2. {ECO:0000250, ECO:0000269|PubMed:11278723, ECO:0000269|PubMed:12637535}.
    亞細胞定位: Endoplasmic reticulum membrane {ECO:0000269|PubMed:9637683}; Single-pass type I membrane protein {ECO:0000269|PubMed:9637683}.
    組織特異性: Ubiquitously expressed. High levels observed in pancreatic tissue. {ECO:0000269|PubMed:9637683}.
    翻譯後修飾: Autophosphorylated. {ECO:0000269|PubMed:9637683}.; ADP-ribosylated by PARP16 upon ER stress, which increases both kinase and endonuclease activities.
    相似的序列: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. {ECO:0000255|PROSITE-ProRule:PRU00159}.; Contains 1 KEN domain. {ECO:0000255|PROSITE-ProRule:PRU00725}.; Contains 1 protein kinase domain. {ECO:0000255|PROSITE-ProRule:PRU00159}.
    General information above from UniProt

    IRE1/ERN1 別稱

    IRE1,IRE1P,IRE1a,hIRE1p, [homo-sapiens]
    ERN1,FLJ30999,hIRE1p,IRE1,IRE1a,IRE1P,MGC163277,MGC163279, [human]
    Ire1p,9030414B18Rik,AI225830,C85377,Ern1,Ire1a,Ire1alpha,RP23-418O11.11-001, [mouse]
    Ire1a,Ire1p,C85377,AI225830,Ire1alpha,9030414B18Rik, [mus-musculus]

    IRE1/ERN1 相關文獻

  • Trentmann,S.M. et al., 2000, Plant Mol Biol. 44 (1):11-25.
  • Iwawaki T., et al., 2001, Nat. Cell Biol. 3:158-64.
  • Liu C.Y., et al., 2003, J. Biol. Chem. 278:17680-7.
  • Oppermann F.S., et al., 2009, Mol. Cell. Proteomics 8:1751-64.
  • 請注意:所有產品都是“僅用於科研,而不能用於診斷或治療用途”