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EphB3 / HEK2 抗體, 兔多抗, 抗原親和純化

產品資料評論相關產品實驗方法
Human EPHB3 抗體產品資訊
免疫原:Recombinant Human EPHB3 / HEK2 protein (Catalog#13925-H20B1)
Clone ID:
Ig類型:Rabbit IgG
濃度:
內毒素:
緩衝液:0.2 μm filtered solution in PBS with 5% trehalose
抗體製備方法:Produced in rabbits immunized with purified, recombinant Human EPHB3 / HEK2 (rh EPHB3 / HEK2; Catalog#13925-H20B1; P54753; Gln585-Val998). EPHB3 / HEK2 specific IgG was purified by Human EPHB3 / HEK2 affinity chromatography.
Human EPHB3 抗體使用指導
特異性:Human EPHB3 / HEK2
推薦應用:ELISA, IHC-P

ELISA: 0.1-0.2 μg/mL

This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Human EPHB3 / HEK2. The detection limit for Human EPHB3 / HEK2 is approximately 0.00975 ng/well.

IHC-P: 0.1-2 μg/mL

儲存方法:This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Human EPHB3 Antibody IHC Application Image
EphB3 / HEK2 Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
[點擊查看大圖]
Caption:
Immunochemical staining of human EPHB3 in human brain with rabbit polyclonal antibody (1 µg/mL, formalin-fixed paraffin embedded sections).
EphB3 / HEK2 Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
[點擊查看大圖]
Caption:
Immunochemical staining of human EPHB3 in human cirrhosis with rabbit polyclonal antibody (1 µg/mL, formalin-fixed paraffin embedded sections).
EphB3 / HEK2 Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
[點擊查看大圖]
Caption:
Immunochemical staining of human EPHB3 in human colon with rabbit polyclonal antibody (1 µg/mL, formalin-fixed paraffin embedded sections).
EphB3 / HEK2 Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
[點擊查看大圖]
Caption:
Immunochemical staining of human EPHB3 in human colon carcinoma with rabbit polyclonal antibody (1 µg/mL, formalin-fixed paraffin embedded sections).
EphB3 / HEK2 Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
[點擊查看大圖]
Caption:
Immunochemical staining of human EPHB3 in human gastric cancer with rabbit polyclonal antibody (1 µg/mL, formalin-fixed paraffin embedded sections).
Other EPHB3 Antibody Products
EphB3/HEK2/Eph Receptor B3 研究背景

Ephrin type-B receptor 3, also known as EphB3 or HEK2, belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family which 16 known receptors (14 found in mammals) are involved: EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHA9, EPHA10, EPHB1, EPHB2, EPHB3, EPHB4, EPHB5, EPHB6. The Eph family of receptor tyrosine kinases (comprising EphA and EphB receptors) has been implicated in synapse formation and the regulation of synaptic function and plasticity6. Ephrin receptors are components of cell signalling pathways involved in animal growth and development, forming the largest sub-family of receptor tyrosine kinases (RTKs). Ligand-mediated activation of Ephs induce various important downstream effects and Eph receptors have been studied for their potential roles in the development of cancer. EphB receptor tyrosine kinases are enriched at synapses, suggesting that these receptors play a role in synapse formation or function. We find that EphrinB binding to EphB induces a direct interaction of EphB with NMDA-type glutamate receptors. This interaction occurs at the cell surface and is mediated by the extracellular regions of the two receptors, but does not require the kinase activity of EphB.

Human EphB3/HEK2/Eph Receptor B3 參考資料
  • Bergemann AD, et al. (1998) Ephrin-B3, a ligand for the receptor EphB3, expressed at the midline of the developing neural tube. Oncogene. 16(4): 471-80.
  • Hock B, et al. (1998) PDZ-domain-mediated interaction of the Eph-related receptor tyrosine kinase EphB3 and the ras-binding protein AF6 depends on the kinase activity of the receptor. Proc Natl Acad Sci U S A. 95(17): 9779-84.
  • Liu X, et al. (2006) EphB3: an endogenous mediator of adult axonal plasticity and regrowth after CNS injury. J Neurosci. 26(12): 3087-101.
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    貨號: 13925-RP02-50
    目錄價: 
    單價:      (You Save: )
    All information of our products is subject to change without notice. Please refer to COA enclosed in shipped package for the newest information.
    請注意:所有產品都是“僅用於科研,而不能用於診斷或治療用途”