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EphA1/Eph Receptor A1  Protein, Antibody, ELISA Kit, cDNA Clone

表達宿主: Human Cells  
15789-H08H-20
15789-H08H-100
20 µg 
100 µg 
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表達宿主: Human Cells  
15789-H02H-20
15789-H02H-100
20 µg 
100 µg 
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  • Slide 1
表達宿主: Human Cells  
50827-M08H-200
50827-M08H-100
200 µg 
100 µg 
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  • Slide 1

EphA1/Eph Receptor A1 相关研究领域

EphA1/Eph Receptor A1 相關信號通路

EphA1/Eph Receptor A1 相關蛋白、抗體、cDNA基因、ELISA試劑盒

EphA1/Eph Receptor A1 概述&蛋白信息

EphA1/Eph Receptor A1 研究背景

基因概述: This EPHA1 gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This EPHA1 gene is expressed in some human cancer cell lines and has been implicated in carcinogenesis. [provided by RefSeq, Jul 2008]
General information above from NCBI
催化活性: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. {ECO:0000255|PROSITE-ProRule:PRU10028}.
亞單位結構: Homodimer. Forms a signaling complex with LCK; PTK2B/PYK2 and PI3-kinase upon activation by EFNA1; regulates T-lymphocytes migration. Interacts (via SAM domain) with ILK (via ANK repeats); stimulated by EFNA1 but independent of the kinase activity of EPHA1. Interacts (kinase activity-dependent) with PTK2/FAK1. {ECO:0000269|PubMed:17634955, ECO:0000269|PubMed:19118217}.
亞細胞定位: Cell membrane {ECO:0000269|PubMed:19118217}; Single-pass type I membrane protein {ECO:0000269|PubMed:19118217}.
組織特異性: Overexpressed in several carcinomas.
翻譯後修飾: Phosphorylated. Autophosphorylation is stimulated by its ligand EFNA1.; Ubiquitinated. {ECO:0000269|PubMed:20596523}.
相似的序列: Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily. {ECO:0000255|PROSITE-ProRule:PRU00159}.; Contains 1 Eph LBD (Eph ligand-binding) domain. {ECO:0000255|PROSITE-ProRule:PRU00883}.; Contains 2 fibronectin type-III domains. {ECO:0000255|PROSITE-ProRule:PRU00316}.; Contains 1 protein kinase domain. {ECO:0000255|PROSITE-ProRule:PRU00159}.; Contains 1 SAM (sterile alpha motif) domain. {ECO:0000255|PROSITE-ProRule:PRU00184}.
General information above from UniProt

EPHA1 or EPH receptor A1 belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. An important role of Eph receptors and their ligands ephrins is to mediate cell-contact-dependent repulsion. Eph receptors and ephrins also act at boundaries to channel neuronal growth cones along specific pathways, restrict the migration of neural crest cells, and via bidirectional signaling prevent intermingling between hindbrain segments. Eph receptors and ephrins can also trigger an adhesive response of endothelial cells and are required for the remodeling of blood vessels. Eph receptors and ephrins have emerged as key regulators of the repulsion and adhesion of cells that underlie the establishment, maintainence, and remodeling of patterns of cellular organization. The ephrins and Eph receptors are implicated as positional labels that may guide the development of neural topographic maps.

EphA1/Eph Receptor A1 別稱

EPH,EPHT,EPHT1, [homo-sapiens]
EPHT,EPHT1,EPH,MGC163163, [human]
5730453L17Rik,AL033318,Eph,Esk, [mouse]
Eph,Esk,AL033318,5730453L17Rik, [mus-musculus]

EphA1/Eph Receptor A1 相關文獻

  • Flanagan JG, et al. (1998) THE EPHRINS AND EPH RECEPTORS IN NEURAL DEVELOPMENT. Annual Review of Neuroscience. 21: 309-45.
  • Wilkinson DG (2000) Eph receptors and ephrins: Regulators of guidance and assembly. International Review of Cytology. 196: 177-244.
  • Zhou R. (1998) The Eph family receptors and ligands. Pharmacol. 77 (3): 151-81.
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