ENO1: ENO1 Protein | ENO1 Antibody

ENO1 Gene family

ENO1 Background

The ENO1 gene encodes a multifunctional enzyme that has been identified as a key component of the glycolytic pathway. ENO1 overexpression and post-translational modifications could be of diagnostic and prognostic value in many cancer types. The results of the ENO1 expression profiling of ovarian follicles suggest that ENO1 may play an important dual role in the progress of follicular development, where ENO1 acts as a glycolytic enzyme and also mediates apoptosis. ENO1 overexpression could make the primary culture follicle granulosa cells in vitro improve progesterone secretion. The over-expression of ENO1 protein can enhance the abilities of proliferation and migration in gastric cancer cells of AGS, which indicates that ENO1 may be an important potential tumor-marker associated with the development of gastric cancer. ENO1 and GPI can be used as markers of human sperm freezability before starting the cryopreservation procedure. The inhibition of ENO1 expression may be a novel strategy for therapy for NHLs patients, and it may be a target for drug resistance.

Reference for ENO1

  • Zhu X, et al. (2015) Eno1 promotes tumor proliferation and cell adhesion mediated drug resistance (cam-dr) in non-hodgkin's lymphomas. Exp Cell Res 335(2), 216-223.
  • Jiang XP, et al. (2015) Enolase1 (eno1) and glucose-6-phosphate isomerase (gpi) are good markers to predict human sperm freezability. Cryobiology 71(1), 141-145.
  • Liu YQ, et al. (2015) Effects of alpha-enolase (eno1) over-expression on malignant biological behaviors of ags cells. Int J Clin Exp Med 8(1), 231-239.
  • Cappello P, et al. (2017) Alpha-enolase (eno1), a potential target in novel immunotherapies. Front Biosci (Landmark Ed) 22(944-959.
  • Zhang WH, et al. (2014) [granulosa cells model transfected by eno1 overexpression adenovirus vector and the effect of eno1 overexpression on progesterone secretion]. Zhongguo Ying Yong Sheng Li Xue Za Zhi 30(1), 85-88.
  • Kang B, et al. (2014) Molecular characterisation and expression profiling of the eno1 gene in the ovarian follicle of the sichuan white goose. Mol Biol Rep 41(4), 1927-1935.
  • Capello M, et al. (2011) a-Enolase: a promising therapeutic and diagnostic tumor target. FEBS J. 278(7): 1064-74.
  • Kang HJ, et al. (2008) Structure of human alpha-enolase (hENO1), a multifunctional glycolytic enzyme. Acta Crystallogr D Biol Crystallogr. 64(Pt 6): 651-7.
  • Lopez-Alemany R, et al. (2005) Alpha-enolase plasminogen receptor in myogenesis. Front Biosci. 10: 30-6.
  • Ejeskdr K, et al. (2005) Introduction of in vitro transcribed ENO1 mRNA into neuroblastoma cells induces cell death. BMC Cancer. 5: 161.

ENO1 Protein

ENO1 protein function

Multifunctional enzyme that, as well as its role in glycolysis, plays a part in various processes such as growth control, hypoxia tolerance and allergic responses. May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons. Stimulates immunoglobulin production.; MBP1 binds to the myc promoter and acts as a transcriptional repressor. May be a tumor suppressor.

ENO1 protein expression

Tissue specificity

The alpha/alpha homodimer is expressed in embryo and in most adult tissues. The alpha/beta heterodimer and the beta/beta homodimer are found in striated muscle, and the alpha/gamma heterodimer and the gamma/gamma homodimer in neurons.

Induction

Induced in diffuse large cell lymphoma (DLCL) after treatment with the natural biological agent, Bryo1. Up-regulated in response to enterovirus 71 (EV71) infection (at protein level).

ENO1 protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    434.00
  • Mass (Da)
    47.00

ENO1 Antibody

There are 6 ENO1 antibodies which are validated in multiple tissues with various applications, including WB, IP, ELISA. There are 3 ENO1 antibody for WB, 2 ENO1 antibody for IP, 5 ENO1 antibody for ELISA. Among all these ENO1 antibodies, there are 5 anti-ENO1 rabbit polyclonal antibodies , 1 anti-ENO1 rabbit monoclonal antibodies . All the ENO1 anbodies are produced in house and all are in stock. ENO1 antibody customerized service is available.

ENO1 Gene

ENO1 gene / cDNA is a protein-coding gene which located on 1p36.23. The ENO1 gene is conserved in chimpanzee, Rhesus monkey, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, A.thaliana, and frog.205 organisms have orthologs with human gene ENO1.