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EGFR / HER1 / ErbB1 中和抗體

  • EGFR / HER1 / ErbB1 Neutralizing Antibody
產品資料評論相關產品實驗方法
 EGFR 抗體產品資訊
免疫原:Recombinant Human EGFR / HER1 / ErbB1 Protein (Catalog#10001-H08H)
Clone ID:RE10
Ig類型:Rabbit IgG
濃度:
內毒素:< 3 EU/mg
緩衝液:0.2 μm filtered solution in Histidine and Arginine buffer containing 120mM NaCl, 0.02% Tween 80, pH6.0
抗體製備方法:This antibody was obtained from a rabbit immunized with purified, recombinant Human EGFR / HER1 / ErbB1 (rh EGFR / HER1 / ErbB1; Catalog#10001-H08H; NP_005219; Met1-Ser645) and was produced using recombinant antibody technology.
 EGFR Antibody Neutralization Application Image
EGFR / HER1 / ErbB1 Neutralizing Antibody
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Caption:
Cell Proliferation Induced by Autocrine EGF was Neutralized by Human EGFR Antibody. Autocrine EGF stimulates proliferation in the human breast cancer MDA-MB-468 cell line. Proliferation elicited by Autocrine EGF is neutralized by increasing concentrations of Human EGFR Monoclonal Antibody (Catalog 10001-RE10). The IC50 is typically 0.05-0.2 μg/mL.
Other EGFR Antibody Products
Immunochemical staining of human CD40 in human tonsil with rabbit polyclonal antibody (0.5 µg/mL, formalin-fixed paraffin embedded sections).
EGFR/HER1 研究背景

As a member of the epidermal growth factor receptor (EGFR) family, EGFR protein is type I transmembrane glycoprotein that binds a subset of EGF family ligands including EGF, amphiregulin, TGF-α, betacellulin, etc. EGFR protein plays a crucial role in signaling pathway in the regulation of cell proliferation, survival and differentiation. Binding of a ligand induces EGFR protein homo- or heterodimerization, the subsequent tyrosine autophosphorylation and initiates various down stream pathways (MAPK, PI3K/PKB and STAT). In addition, EGFR signaling also has been shown to exert action on carcinogenesis and disease progression, and thus EGFR protein is proposed as a target for cancer therapy currently.

Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

 EGFR/HER1 參考資料
  • Schlessinger, J. (2000) Cell signaling by receptor tyrosine kinases. Cell 103(2): 211-25.
  • Giaccone, G. (2005) HER1/EGFR-targeted agents: predicting the future for patients with unpredictable outcomes to therapy. Ann. Oncol. 16(4): 538-48.
  • Yarden, Y., et al. (2001) Untangling the ErbB signalling network. Nat. Rev. Mol. Cell. Biol. 2(2): 127-37.
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    Size / Price
    貨號: 10001-RE10-200
    目錄價: 
    單價:      (You Save: )

    Datasheet & Documentation

    All information of our products is subject to change without notice. Please refer to COA enclosed in shipped package for the newest information.
    請注意:所有產品都是“僅用於科研,而不能用於診斷或治療用途”