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EGFR / HER1 / ErbB1 抗體, 兔單抗

  • EGFR / HER1 / ErbB1 Antibody, Rabbit MAb, Immunofluorescence
  • EGFR / HER1 / ErbB1 Antibody, Rabbit MAb, Immunohistochemistry
  • EGFR / HER1 / ErbB1 Antibody, Rabbit MAb, Immunohistochemistry
  • EGFR / HER1 / ErbB1 Antibody, Rabbit MAb, Immunohistochemistry
產品資料評論相關產品實驗方法
 EGFR/ErbB1/HER1 抗體產品資訊
免疫原:Recombinant Human EGFR / HER1 / ErbB1 protein (Catalog#10001-H08H)
Clone ID:043
Ig類型:Rabbit IgG
濃度:
內毒素:
緩衝液:0.2 μm filtered solution in PBS
抗體製備方法:This antibody was obtained from a rabbit immunized with purified, recombinant Human EGFR / HER1 / ErbB1 (rh EGFR / HER1 / ErbB1; Catalog#10001-H08H; NP_005219; Met 1-Ser 645).
 EGFR/ErbB1/HER1 Antibody IHC Application Image
EGFR / HER1 / ErbB1 Antibody, Rabbit MAb, Immunofluorescence
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Caption:
Immunofluorescence staining of EGFR in monkey skin with rabbit monoclonal antibody (20 μg/mL, frozen section). The image showing membrane staining of squamous epithelium cell.
EGFR / HER1 / ErbB1 Antibody, Rabbit MAb, Immunohistochemistry
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Caption:
Immunochemical staining of human EGFR in human placenta with rabbit monoclonal antibody (5 µg/mL,formalin-fixed paraffin embedded sections). Positive staining was localized to trophoblast.
EGFR / HER1 / ErbB1 Antibody, Rabbit MAb, Immunohistochemistry
[點擊查看大圖]
Caption:
Immunochemical staining of human EGFR in human rectal cancer with rabbit monoclonal antibody (5 µg/mL, formalin-fixed paraffin embedded sections). Positive staining was localized to rectal gland. The left panel: tissue incubated with primary antibody; The right panel: tissue incubated with the mixture of primary antibody and antigen (recombinant protein).
EGFR / HER1 / ErbB1 Antibody, Rabbit MAb, Immunohistochemistry
[點擊查看大圖]
Caption:
Immunochemical staining of human EGFR in human uterine cervix cancer with rabbit monoclonal antibody (5 µg/mL, formalin-fixed paraffin embedded sections). Positive staining was localized to uterine gland.
Other EGFR/ErbB1/HER1 Antibody Products
EGFR/HER1 研究背景

As a member of the epidermal growth factor receptor (EGFR) family, EGFR protein is type I transmembrane glycoprotein that binds a subset of EGF family ligands including EGF, amphiregulin, TGF-α, betacellulin, etc. EGFR protein plays a crucial role in signaling pathway in the regulation of cell proliferation, survival and differentiation. Binding of a ligand induces EGFR protein homo- or heterodimerization, the subsequent tyrosine autophosphorylation and initiates various down stream pathways (MAPK, PI3K/PKB and STAT). In addition, EGFR signaling also has been shown to exert action on carcinogenesis and disease progression, and thus EGFR protein is proposed as a target for cancer therapy currently.

Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

 EGFR/HER1 參考資料
  • Schlessinger, J. (2000) Cell signaling by receptor tyrosine kinases. Cell 103(2): 211-25.
  • Giaccone, G. (2005) HER1/EGFR-targeted agents: predicting the future for patients with unpredictable outcomes to therapy. Ann. Oncol. 16(4): 538-48.
  • Yarden, Y., et al. (2001) Untangling the ErbB signalling network. Nat. Rev. Mol. Cell. Biol. 2(2): 127-37.
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    Size / Price
    貨號: 10001-R043-50
    目錄價: 
    單價:      (You Save: )

    Datasheet & Documentation

    All information of our products is subject to change without notice. Please refer to COA enclosed in shipped package for the newest information.
    請注意:所有產品都是“僅用於科研,而不能用於診斷或治療用途”