Anti-EGFR Antibody (Rabbit Monoclonal antibody) General Information
Reacts with: Mouse
Mouse EGFR No cross-reactivity in ELISA with Human EGFR Mouse ERBB2 Mouse ERBB4 Rat EGFR
Recombinant Mouse EGFR / ErbB1 / HER1 protein (Catalog#51091-M08H)
This antibody was obtained from a rabbit immunized with purified, recombinant Mouse EGFR / ErbB1 / HER1 (rM EGFR / ErbB1 / HER1; Catalog#51091-M08H; Q01279; Met1-Ser647).
Monoclonal Rabbit IgG Clone #112
0.2 μm filtered solution in PBS
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.
As a member of the epidermal growth factor receptor (EGFR) family, EGFR protein is type I transmembrane glycoprotein that binds a subset of EGF family ligands including EGF, amphiregulin, TGF-α, betacellulin, etc. EGFR protein plays a crucial role in signaling pathway in the regulation of cell proliferation, survival and differentiation. Binding of a ligand induces EGFR protein homo- or heterodimerization, the subsequent tyrosine autophosphorylation and initiates various down stream pathways (MAPK, PI3K/PKB and STAT). In addition, EGFR signaling also has been shown to exert action on carcinogenesis and disease progression, and thus EGFR protein is proposed as a target for cancer therapy currently.
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